INFORMATION TECHNOLOGY AND BIOSTATISTICS CORE

资讯科技及广播局的长远目标，是提供先进的资讯科技及专业知识， 度量建模和生物统计学，以支持匹兹堡大学COPD的SSCOR。这 信息技术（IT）系统将允许基础和临床研究结果组织在一个 质量控制，数据集市，以允许分析，药理学建模和统计分析， 支持本提案中包含的所有项目。该研究计划将实现 为了实现既定目标，必须遵循具体目标。 具体目标1：为所有调查人员、所有项目（特别是 项目1、2和3）以及本提案中的所有核心。 具体目标2：为所有项目提供统计和数学建模能力 （特别是项目1和项目3）。 具体目标3：为所有人开发数据挖掘和在线分析处理的新方法 项目在这个提案中。 拟议的ITBC是从临床中心内部的现有核心资源建立的， 药理学，匹兹堡大学。临床药理学中心目前的资源有 拥有丰富的经验，能够支持NIH资助的多个项目。该中心的 能力允许完善的、功能齐全的、基本的临床研究基础设施支持 该系统将立即提供给匹兹堡大学COPD的SSCOR。

The long-term objective of the ITBC is to provide advanced information technology and skilled expertise in metric modeling and biostatistics to support the SSCOR in COPD at the University of Pittsburgh. This Information Technology (IT) system will allow basic and clinical research findings to be organized in a quality-controlled, data mart to permit analyses, pharmacometric modeling, and statistical analyses to support all of the projects included within this proposal. The research proposal will accomplish the following specific aims in order to achieve stated objectives. Specific Aim 1: To provide comprehensive IT support to all investigators, all projects (especially project 1, 2, and 3), and all cores in this proposal. Specific Aim 2: To provide statistical and mathematical modeling capabilities to all projects (especially intensive for project 1 and project 3) in this proposal. Specific Aim 3: To develop novel methods for data mining and online-analytical processing for all projects in this proposal. The proposed ITBC is being built from an existing core resource from within the Center for Clinical Pharmacology, University of Pittsburgh. The current resource at the Center for Clinical Pharmacology has extensive experience and is capable of supporting a number of NIH-funded projects. The Center's capabilities permit a well-established, fully functional, essential clinical research infrastructure support system to be immediately available to the SSCOR in COPD at the University of Pittsburgh.