INFORMATION TECHNOLOGY AND BIOSTATISTICS CORE

资讯科技及广播局的长远目标是提供先进的资讯科技和专业知识。 支持匹兹堡大学慢性阻塞性肺病SSCOR的度量模型和生物统计学。这 信息技术(IT)系统将允许基础和临床研究成果以 质量受控的数据集市，允许分析、药物计量建模和统计分析 支持本提案中包括的所有项目。该研究方案将实现 为了达到既定的目标而遵循特定的目标。 具体目标1：为所有调查人员、所有项目(特别是 项目1、2和3)，以及本提案中的所有核心。 具体目标2：向所有项目提供统计和数学建模能力 (特别是对项目1和项目3)。 具体目标3：为所有人开发数据挖掘和在线分析处理的新方法 本提案中的项目。 拟议的ITBC是在临床中心内现有的核心资源基础上建立的 匹兹堡大学药理学专业。临床药理学中心目前的资源有 经验丰富，有能力支持多个由NIH资助的项目。该中心的 能力允许建立完善的、功能齐全的、基本的临床研究基础设施支持 该系统将立即提供给匹兹堡大学慢性阻塞性肺病的SSCOR。

The long-term objective of the ITBC is to provide advanced information technology and skilled expertise in metric modeling and biostatistics to support the SSCOR in COPD at the University of Pittsburgh. This Information Technology (IT) system will allow basic and clinical research findings to be organized in a quality-controlled, data mart to permit analyses, pharmacometric modeling, and statistical analyses to support all of the projects included within this proposal. The research proposal will accomplish the following specific aims in order to achieve stated objectives. Specific Aim 1: To provide comprehensive IT support to all investigators, all projects (especially project 1, 2, and 3), and all cores in this proposal. Specific Aim 2: To provide statistical and mathematical modeling capabilities to all projects (especially intensive for project 1 and project 3) in this proposal. Specific Aim 3: To develop novel methods for data mining and online-analytical processing for all projects in this proposal. The proposed ITBC is being built from an existing core resource from within the Center for Clinical Pharmacology, University of Pittsburgh. The current resource at the Center for Clinical Pharmacology has extensive experience and is capable of supporting a number of NIH-funded projects. The Center's capabilities permit a well-established, fully functional, essential clinical research infrastructure support system to be immediately available to the SSCOR in COPD at the University of Pittsburgh.