DRUG METABOLISM IN HEAD AND NECK CANCER

头颈癌中的药物代谢

• 批准号: 6245616
• 负责人: ROBERT A BRANCH
• 金额: $ 1.76万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-18 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245616
• 关键词: cancer risk; clinical research; drug metabolism; enzyme activity; gene mutation; head /neck neoplasm; human genetic material tag; human subject; messenger RNA; natural gene amplification; neoplasm /cancer genetics; oncogenes; phenotype

The objective of this case controlled study in head and neck cancer is to determine if phenotypic measures of drug metabolizing activity as measured by the Pittsburgh drug cocktail in the whole body or from quantitation of mRNA from individual drug metabolizing enzymes in oral cavity mucosa or tumor will be related to the risk of developing head and neck cancer. Measures of drug metabolizing activity will also be related to specific mutation of oncogene amplification as well as the biological behavior of the tumor.

这个头颈癌病例对照研究的目的是