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DRUG METABOLISM IN HEAD AND NECK CANCER

DRUG METABOLISM IN HEAD AND NECK CANCER
头颈癌中的药物代谢
批准号：
6245616
负责人：
ROBERT A BRANCH
金额：
$1.76万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-03-18 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6245616
关键词：
cancer risk clinical research drug metabolism enzyme activity gene mutation head /neck neoplasm human genetic material tag human subject messenger RNA natural gene amplification neoplasm /cancer genetics oncogenes phenotype

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中文摘要
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英文摘要
The objective of this case controlled study in head and neck cancer is to determine if phenotypic measures of drug metabolizing activity as measured by the Pittsburgh drug cocktail in the whole body or from quantitation of mRNA from individual drug metabolizing enzymes in oral cavity mucosa or tumor will be related to the risk of developing head and neck cancer. Measures of drug metabolizing activity will also be related to specific mutation of oncogene amplification as well as the biological behavior of the tumor.
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会议论文
Community Appalachian Investigation and Research Network (CAIRN)
INFORMATION TECHNOLOGY AND BIOSTATISTICS CORE
VALIDATION OF MODIFIED PITTSBURGH COCKTAIL STUDY
WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJ
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