CYTOKINE EXPRESSION OF LPS STIMULATED ENDOTHELIAL CELLS

LPS 刺激的内皮细胞的细胞因子表达

• 批准号: 6246060
• 负责人: G S WORTHEN
• 金额: $ 1.71万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246060
• 关键词: adult respiratory distress syndrome; cell cell interaction; cellular pathology; cytokine; human subject; lipopolysaccharides; neutrophil; pathologic process; vascular endothelium

This study will reveal mechanisms by which cells in the vasculature (curculating and fixed) respond to LPS and cytokines. The responses of neutrophils and endothelial cells, and their subsequent interaction with each other, contribute to the pathogenesis of ARDS. The mechanisms explored here may present attractive targets for therapeutic attempts.

这项研究将揭示血管系统中的细胞 （循环和固定）响应LPS和细胞因子。 的答复 中性粒细胞和内皮细胞，以及它们随后与 相互作用，共同参与了ARDS的发病机制。 的机制 这里探索的可能为治疗尝试提供有吸引力的靶点。