ALPHA2 ADRENERGIC RECEPTOR DYSFUNCTION IN PATIENTS WITH REGIONAL LIPOATROPHY

区域性脂肪萎缩患者的 ALPHA2 肾上腺素能受体功能障碍

• 批准号: 6246342
• 负责人: CHARLES A STUART
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-06 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246342
• 关键词: alpha adrenergic agent; alpha adrenergic receptor; antiadrenergic agents; clinical research; human subject; lipid metabolism; lipodystrophy; nucleic acid sequence; structural genes

Partial or total lipoatrophy is characterized by insulin resistant diabetes, hypertiglyceridemia, fatty infiltration of the liver, and hypertension. The etiology of this syndrome is unknown. The alpha2 adrenergic receptor is a Gi-dependent system which normally antagonizes the lipolytic effects of beta adrenergic agonists primarily in peripheral fat depots and antagonizes alpha1 adrenergic effects on vascular resistance. A defective alpha2 adrenergic receptor would likely result in accelerated lipolysis in peripheral fat depots thus resulting in a disappearance of fat in these regions and favoring accumulation in visceral and trunk depots. Such a defect would also tend to increase blood pressure. We propse to evaluate the function of the alpha2 adrenergic receptor in subjects with regional lipoatrophy by in vivo testing of the response to alpha2 adrenergic receptor agonists and antagonists and we will sequence the structural gene for the alpha2 adrenergic receptor in these patients.

部分或全部脂肪萎缩的特征是胰岛素抵抗 糖尿病、高甘油三酯血症、肝脏脂肪浸润，以及 高血压这种综合征的病因尚不清楚。阿尔法2 肾上腺素能受体是一种Gi依赖性系统，通常拮抗 β肾上腺素能激动剂的脂解作用主要在 外周脂肪库和拮抗α 1肾上腺素能作用， 血管阻力 有缺陷的α 2肾上腺素能受体 可能导致外周脂肪库加速脂解 导致这些区域的脂肪消失， 在内脏和躯干中蓄积。 这种缺陷也会 会增加血压 我们建议评估的功能 局部脂肪萎缩受试者的α 2肾上腺素能受体 对α 2肾上腺素能受体激动剂的反应的体内测试 和拮抗剂，我们将测序α 2的结构基因， 肾上腺素能受体。