ALPHA2 ADRENERGIC RECEPTOR DYSFUNCTION IN PATIENTS WITH REGIONAL LIPOATROPHY

部分或全部脂肪萎缩的特征是胰岛素抵抗。 糖尿病，高甘油三酯血症，肝脏脂肪渗透，以及 高血压。这种综合征的病因尚不清楚。字母2 肾上腺素能受体是一种依赖胃肠道的系统，通常会拮抗 β-肾上腺素能激动剂的脂解作用主要在 外周脂肪储备和拮抗α1肾上腺素能作用 血管阻力。一个有缺陷的α2肾上腺素能受体会 可能导致外周脂肪加速分解，从而 导致这些区域的脂肪消失，有利于 在内脏和躯干仓库中积累。这样的缺陷也会 往往会使血压升高。我们建议对其功能进行评估 局部脂肪萎缩受试者的α2肾上腺素能受体 α2肾上腺素能受体激动剂的体内反应测试 和拮抗剂，我们将对α2的结构基因进行测序 这些患者的肾上腺素能受体。

Partial or total lipoatrophy is characterized by insulin resistant diabetes, hypertiglyceridemia, fatty infiltration of the liver, and hypertension. The etiology of this syndrome is unknown. The alpha2 adrenergic receptor is a Gi-dependent system which normally antagonizes the lipolytic effects of beta adrenergic agonists primarily in peripheral fat depots and antagonizes alpha1 adrenergic effects on vascular resistance. A defective alpha2 adrenergic receptor would likely result in accelerated lipolysis in peripheral fat depots thus resulting in a disappearance of fat in these regions and favoring accumulation in visceral and trunk depots. Such a defect would also tend to increase blood pressure. We propse to evaluate the function of the alpha2 adrenergic receptor in subjects with regional lipoatrophy by in vivo testing of the response to alpha2 adrenergic receptor agonists and antagonists and we will sequence the structural gene for the alpha2 adrenergic receptor in these patients.