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INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS

INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS
胰岛素抵抗、多囊卵巢疾病和黑棘皮症
批准号:
6276376
负责人:
CHARLES A STUART
金额:
$2.69万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30

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项目成果

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中文摘要
翻译
黑棘皮病是一种常见的皮肤损害,表明 内源性高胰岛素血症。我们假设有这种皮肤的患者 病变在胰岛素作用方面存在各种遗传性缺陷,所有 它们与相似的表型相关,并且非 胰岛素依赖型糖尿病。受试者将服用胰岛素 响应性每年评估一次,并选择受严重影响的对象 他们的父母将对胰岛素受体基因进行评估 点突变。
英文摘要
Acanthosis nigricans is a commonly occurring skin lesion which indicates endogenous hyperinsulinemia. We hypothesize that patients with this skin lesion have a variety of hereditary defects in insulin action, all of which are associated with a similar phenotype and a high risk for non- insulin dependent diabetes mellitus. Subjects will have insulin responsiveness evaluated annually, and selected severely affected subjects and their parents will have evaluation of the insulin receptor gene for point mutations.
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Mechanisms by which strength training ameliorates the Metabolic Syndrome
  • 批准号:
    8006750
  • 项目类别:
  • 资助金额:
    $0.67万
  • 财政年份:
    2010
  • 负责人:
    CHARLES A STUART
  • 依托单位:
Mechanisms by which exercise training ameliorates the metabolic syndrome
  • 批准号:
    8035605
  • 项目类别:
  • 资助金额:
    $38.72万
  • 财政年份:
    2008
  • 负责人:
    CHARLES A STUART
  • 依托单位:
Mechanisms by which strength training ameliorates the Metabolic Syndrome
  • 批准号:
    7522195
  • 项目类别:
  • 资助金额:
    $21.3万
  • 财政年份:
    2008
  • 负责人:
    CHARLES A STUART
  • 依托单位:
INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS
海外基金