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INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS

INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS
胰岛素抵抗、多囊卵巢疾病和黑棘皮症
批准号：
6276376
负责人：
CHARLES A STUART
金额：
$2.69万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6276376
关键词：
acanthosis nigricans clinical research diabetes mellitus genetics disease /disorder proneness /risk family genetics female human genetic material tag human subject insulin receptor insulin sensitivity /resistance noninsulin dependent diabetes mellitus point mutation polycystic ovary syndrome

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中文摘要
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英文摘要
Acanthosis nigricans is a commonly occurring skin lesion which indicates endogenous hyperinsulinemia. We hypothesize that patients with this skin lesion have a variety of hereditary defects in insulin action, all of which are associated with a similar phenotype and a high risk for non- insulin dependent diabetes mellitus. Subjects will have insulin responsiveness evaluated annually, and selected severely affected subjects and their parents will have evaluation of the insulin receptor gene for point mutations.
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INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS
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