Do activated retinal microglia mediate neurotoxicity in background diabetic retinopathy?

激活的视网膜小胶质细胞是否介导背景糖尿病视网膜病变的神经毒性？

• 批准号: nhmrc : 634469
• 负责人: Prof Elizabeth Rakoczy
• 金额: $ 29.05万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activated-retinal-microglia-diabetic-retinopathy/95122
• 关键词: Do; activated; retinal; microglia; mediate

Diabetic retinopathy, a frequent complication of Type 1 and Type 2 diabetes, is the commonest cause of blindness in working age individuals. Prior to the growth of blindness-causing new vessels in the eye we now know that there is a gradual loss of neurons in the retina. This project will investigate whether the resident immune cells in the retina, which are normally neuroprotective, become neurotoxic during episodes of systemic inflammation (e.g. bacterial or viral infections).

糖尿病视网膜病变是 1 型和 2 型糖尿病的常见并发症，是工作年龄人群失明的最常见原因。在导致失明的新血管在眼睛中生长之前，我们现在知道视网膜中的神经元逐渐丧失。该项目将研究视网膜中通常具有神经保护作用的常驻免疫细胞在全身炎症（例如细菌或病毒感染）发作期间是否会变得具有神经毒性。