Discovery and characterisation of long noncoding RNAs in human neurological disorders

人类神经系统疾病中长非编码 RNA 的发现和表征

• 批准号: nhmrc : 1072662
• 金额: $ 23.31万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovery-characterisation-long-neurological-disorders/455523
• 关键词: Discovery; characterisation; long; noncoding; RNAs

Numerous regions in our DNA influence how likely we are to develop various diseases, including brain disorders such as Autism and Schizophrenia. However, in many of these regions no genes have been found and they appear “empty”, making it difficult to uncover what’s triggering the disease. This project will use a powerful new technology to discover new genes hidden within these supposedly “empty” regions that are important in brain disorders and investigate how they contribute to disease.

我们DNA中的许多区域会影响我们患上各种疾病的可能性，包括自闭症和精神分裂症等大脑疾病。然而，在这些区域中的许多区域没有发现基因，它们看起来是“空的”，这使得很难发现引发疾病的原因。该项目将使用一种强大的新技术来发现隐藏在这些所谓的“空”区域中的新基因，这些基因在大脑疾病中很重要，并研究它们如何导致疾病。