Characterisation, determinants, mechanisms and consequences of the long-term effects of COVID-19: providing the evidence base for health care

我们将回答以下患者定义的问题：什么是Long-COVID，它是如何诊断的？为什么我得了长冠状病毒？长期患有COVID对我的健康、工作能力和家庭有什么影响？我康复的机会有多大？这项研究将如何确保我得到正确的治疗和长期COVID的支持？被称为长期冠状病毒感染的C-19感染对身体和精神健康的影响经常发生。我们对长期COVID的了解很差，包括如何最好地诊断、风险因素、健康和经济后果，限制了帮助人们的努力。我们将结合使用国家匿名链接初级保健电子健康记录，以及对全国所有年龄段的人进行的纵向研究。我们询问了参与者关于C-19感染和长期COVID症状的情况，并在大流行之前收集了多年的健康和社会经济信息。从这些研究中，我们将要求报告长期COVID的人和对照组佩戴腕带，测量运动能力、呼吸和心率，并完成关于心理健康和认知功能的在线问卷。他们还将被邀请到诊所进行非侵入性成像，以查看对重要器官的潜在损害，如大脑、肺和心脏。患者、监督电子健康记录研究的公众成员和研究成员都参与了研究问题的形成，并将在项目期间进行咨询。此外，来自研究的长期COVID患者及其家人将参与形成长期COVID的诊断工具，并帮助我们了解康复的决定因素和对治疗的反应。我们将与参与指南的机构(NICE，他们也是该项目的一部分)、政府(通过出版物)分享研究结果。

We will address the following patient defined questions: What is long-COVID and how is it diagnosed? Why have I got long-COVID? What effects will long-COVID have on my health, ability to work and family? What are my chances of recovery? How will this research ensure I am getting the right treatment and support for long-COVID? Physical and mental health consequences of C-19 infection, termed long-COVID, occur frequently. Our understanding of long-COVID, including how best to diagnose, risk factors, health and economic consequences, is poor, limiting efforts to help people. We will use a combination of national anonymised linked primary care electronic health records, and longitudinal studies of people of all ages across the country. We have asked participants about C-19 infections, long-COVID symptoms, and have collected health and socioeconomic information for many years before the pandemic. From these studies, we will ask people reporting long-COVID, and comparator groups, to wear a wrist band measuring exercise ability, breathing, and heart rate, and complete online questionnaires on mental health and cognitive function. They will also be invited to clinic for non-invasive imaging to look at potential damage to vital organs, such as the brain, lungs and heart. Patients, members of the public overseeing electronic health record research, and study members have been involved in shaping the research questions, and will be consulted for the duration of the project. In addition, people with long-COVID and their families, from the studies, will be involved in shaping the diagnostic tools for long-COVID, and aiding our understanding of determinants of recovery, and responses to therapy. We will share findings with bodies involved in guidelines (NICE, who are also part of this project), with government (via the publications).