Discovery of long CD8+ T cell epitopes uncovers a hidden reservoir of immunodominant, anti-tumour responses

长 CD8 T 细胞表位的发现揭示了免疫显性抗肿瘤反应的隐藏库

• 批准号: nhmrc : 542508
• 负责人: Prof Jonathan Cebon
• 金额: $ 32.01万
• 依托单位: Ludwig Institute for Cancer Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovery-long-cd8-tumour-responses/99685
• 关键词: Discovery; long; CD8+; cell; epitopes

Stimulating killer T cells to eliminate tumours has been one of the ultimate yet elusive goals of cancer vaccine development. Vaccines aimed at stimulating killer T cells are similar to those generated under natural conditions. However, special strategies are needed to vaccinate beneficial killer T cells that are not normally part of the natural immunity. In this project, we will explore such a scenario and dissect the related mechanisms contributing to such differential immune outcomes.

刺激杀伤性T细胞以消除肿瘤一直是癌症疫苗开发的终极目标之一。旨在刺激杀伤性T细胞的疫苗与自然条件下产生的疫苗相似。然而，需要特殊的策略来接种通常不是天然免疫的一部分的有益的杀伤T细胞。在这个项目中，我们将探讨这样的情况，并剖析相关的机制，有助于这种差异的免疫结果。