课题基金 / 基金详情

TRANSCRIPTIONAL REGULATION OF WT-1

TRANSCRIPTIONAL REGULATION OF WT-1
WT-1 的转录调控
批准号：
6102170
负责人：
GRADY F SAUNDERS
金额：
$3.0万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-08-01 至 1999-07-31
来源：
https://reporter.nih.gov/project-details/6102170
关键词：
DNA footprinting RNA splicing RNase protection assay Wilms' tumor gel mobility shift assay gene expression genetic enhancer element genetic library genetic mapping genetic models genetic promoter element genetic regulation genetic regulatory element genetic transcription human genetic material tag in situ hybridization molecular cloning neoplasm /cancer genetics nucleic acid probes nucleic acid sequence reporter genes transcription factor transposon /insertion element

项目摘要

项目成果

GRADY F SAUNDERS的其他基金

相似基金

相关文献

中文摘要
翻译
本项目的目标是了解 肾母细胞瘤WT1基因的转录调控。实验是 旨在鉴定和克隆新的反式作用蛋白(增强剂， 沉默因子、启动子元件)参与WT1表达的调控。 这些交易调节蛋白的遗传位点将是 因为这些基因座上的突变可能在 肾母细胞瘤的发展。
英文摘要
The goal of this project is to understand the major elements involved in transcriptional regulation of the Wilms' tumor WT1 gene. Experiments are designed to identify and clone novel trans-acting proteins (enhancers, silencer, promoter elements) involved in the modulation of WT1 expression. The genetic loci for these transacting regulatory proteins will be determined since mutation at these loci may be important in the development of Wilms' tumor.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ROLE OF WT1 IN GENITOURINARY DEVELOPMENT AND TUMORIGENESIS
ROLE OF WT1 IN GENITOURINARY DEVELOPMENT AND TUMORIGENESIS
TRANSCRIPTIONAL REGULATION OF WT-1
PAX6 FUNCTION AND ANIRIDIA
海外基金