课题基金 / 基金详情

PAX6 FUNCTION AND ANIRIDIA

PAX6 FUNCTION AND ANIRIDIA
PAX6 功能和无虹膜
批准号：
2331654
负责人：
GRADY F SAUNDERS
金额：
$21.91万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
项目状态：
已结题
起止时间：
1992-08-01 至 2000-01-31
来源：
https://reporter.nih.gov/project-details/2331654
关键词：
DNA footprinting congenital eye disorder gel mobility shift assay gene expression gene mutation genetic regulatory element genetic transcription genetically modified animals human genetic material tag human subject iris laboratory mouse molecular cloning molecular genetics northern blottings nucleic acid sequence phenotype polymerase chain reaction protein sequence protein structure function site directed mutagenesis structural genes tissue /cell culture

项目摘要

项目成果

GRADY F SAUNDERS的其他基金

相关文献

中文摘要
翻译
描述：本提案旨在理解如何
英文摘要
DESCRIPTION: This proposal is directed towards understanding how the human PAX6 gene and protein are regulated and identifying target genes regulated by PAX6. The aims are 1) to identify the regulatory elements involved in PAX gene transcription; 2) to determine whether PAX6 regulates its own synthesis; 3)to use in vitro mutagenesis for studies of structure and function of the PAX6 protein; 4) to extend analyses of naturally occurring mutations in aniridia patients and examine the consequences of these mutations by constructing PAX6 expression vectors containing these mutations; and 5) to identify the target genes regulated by PAX6.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ROLE OF WT1 IN GENITOURINARY DEVELOPMENT AND TUMORIGENESIS
ROLE OF WT1 IN GENITOURINARY DEVELOPMENT AND TUMORIGENESIS
TRANSCRIPTIONAL REGULATION OF WT-1
TRANSCRIPTIONAL REGULATION OF WT-1