DNA SEQUENCE ORGANIZATION IN THE WILMS TUMOR LOCUS

Wilms 肿瘤位点的 DNA 序列组织

• 批准号: 3190085
• 负责人: GRADY F SAUNDERS
• 金额: $ 15.85万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-02-01 至 1993-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3190085
• 关键词: DNA; cancer risk; child (0-11); chromosomes; cytogenetics; gene deletion mutation; genetic library; genetic mapping; genetic transcription; hamsters; human genetic material tag; human subject; human tissue; hybrid cells; linkage mapping; molecular cloning; neoplasm /cancer genetics; nephroblastoma; nucleic acid sequence; pediatric neoplasm /cancer

The goal of this project is to identify the site of key genetic events in the development of Wilms' tumors. A genomic DNA library of region p13 on chromosome 11 will be utilized to establish the critical site(s) involved in formation of Wilms' tumor. Experiments are proposed to determine the location and identity of transcribed sequences in the Wilms' tumor gene region on 11p13.

该项目的目标是确定关键遗传位点， Wilms'肿瘤的发展过程中发生的事件。 基因组DNA 11号染色体上p13区的文库将用于 建立参与Wilms'形成的关键位点 肿瘤 实验提出了确定的位置和 肾母细胞瘤基因区转录序列的同一性 在11p13。