IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS STUDY

铁超负荷和遗传性血色病研究是一项流行病学研究，研究对象是铁超负荷和遗传性血色病的患病率、遗传和环境决定因素以及潜在的临床、个人和社会影响，研究对象为多中心、多种族、初级保健的 100,000 名成人样本。这些信息将用于确定针对铁超负荷和遗传性血色素沉着病的初级保健筛查和干预的可行性以及潜在的个人和公共健康益处和风险。将从五个现场中心招募 10 万名参与者进行筛选。筛选后，将对选定的个体进行临床检查。该研究的最后一个组成部分是一项家庭研究，它将使用基因组扫描和连锁评估来识别与铁过载和遗传性血色素沉着病表达相关的遗传变异。

The Iron Overload and Hereditary Hemochromatosis Study is an epidemiologic study of the prevalence, genetic and environmental determinants, and potential clinical, personal, and societal impact of iron overload and hereditary hemochromatosis in a multi-center, multi-ethnic, primary care-based sample of 100,000 adults. The information will be used to determine the feasibility and potential individual and public health benefits and risks of primary care-based screening and intervention for iron overload and hereditary hemochromatosis. The 100,000 participants will be recruited from five field centers for screening. Following the screening, a clinical examination will be conducted in selected individuals. The final component of the study is a family study which will use genome scanning and assessment of linkage to identify genetic variants related to the expression of iron overload and hereditary hemochromatosis disorders.