IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS STUDY

铁过量和遗传性血色素沉着症研究

• 批准号: 6331068
• 负责人: Christine E. Mclaren
• 金额: $ 0.76万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-31 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6331068
• 关键词: clinical research; epidemiology; family genetics; gene environment interaction; genetic polymorphism; genetic screening; genetic susceptibility; hereditary hemochromatosis; human subject; iron disorder; linkage mapping; primary care physician

The Iron Overload and Hereditary Hemochromatosis Study is an epidemiologic study of the prevalence, genetic and environmental determinants, and potential clinical, personal, and societal impact of iron overload and hereditary hemochromatosis in a multi-center, multi-ethnic, primary care-based sample of 100,000 adults. The information will be used to determine the feasibility and potential individual and public health benefits and risks of primary care-based screening and intervention for iron overload and hereditary hemochromatosis. The 100,000 participants will be recruited from five field centers for screening. Following the screening, a clinical examination will be conducted in selected individuals. The final component of the study is a family study which will use genome scanning and assessment of linkage to identify genetic variants related to the expression of iron overload and hereditary hemochromatosis disorders.

铁超载和遗传性血色素沉着症研究是一项流行病学研究，研究了铁超载和遗传性血色素沉着症的患病率、遗传和环境决定因素以及潜在的临床、个人和社会影响，研究对象是10万名多中心、多种族、以初级保健为基础的成年人样本。这些信息将用于确定对铁超载和遗传性血色素沉着症进行基于初级保健的筛查和干预的可行性、潜在的个人和公共健康益处和风险。10万名参与者将从5个实地中心招募进行筛选。筛选后，将对选定的个体进行临床检查。该研究的最后一个组成部分是一项家庭研究，该研究将使用基因组扫描和连锁评估来识别与铁超载和遗传性血色素沉着病表达相关的遗传变异。