BIOSTATISTICS SHARED RESOURCE

生物统计共享资源

• 批准号: 7944566
• 负责人: Christine E. Mclaren
• 金额: $ 14.23万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-06 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944566
• 关键词: Adverse effects; Aleurites; Applications Grants; Biostatistics Core; Biostatistics Shared Resource; Calendar; Cancer Center; Cancer Center Support Grant; Cancer Etiology; Clinical; Clinical Data; Clinical Research; Clinical Research Protocols; Clinical Trials; Consent Forms; Consult; Consultations; Data; Data Analyses; Data Base Management; Data Collection; Data Files; Databases; Detection; Development; Diagnostic Procedure; Dictionary; Eligibility Determination; Endpoint Determination; Evaluation; Experimental Designs; Extramural Activities; Faculty; Follow-Up Studies; Funding; Genetic; Goals; Housing; In Vitro; Laboratories; Link; Manuscripts; Methods; Modality; Modification; Monitor; Patients; Peer Review; Performance; Persons; Pharmaceutical Preparations; Play; Preparation; Prevention; Procedures; Protocols documentation; Quality Control; Randomized; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; Sample Size; Scheme; Services; Staging; Statistical Data Interpretation; Statistical Methods; Statistical Models; Statistical Study; Stratification; Survival Analysis; Testing; Therapeutic; Toxic effect; University of California Irvine Cancer Center; Writing; abstracting; anticancer research; cancer prevention; computer program; data management; database design; design; dosage; epidemiology study; follow-up; genetic analysis; genetic epidemiology; member; prevention clinical trial; professor; protocol development; research and development; statistics; treatment planning; tumor

The primary goal of the Biostatistics Core is to provide consulting services in support of cancer research. The primary activities of the Biostatistics Shared Resource include: 1) statistical and design issues for new studies; 2) statistical analysis of data and consultation; and 3) development of clinical research protocols. The BSR has been involved in data analyses in a wide variety of projects, including genetic epidemiology studies; cancer etiology research; clinical studies to evaluate biblogical markers, assessment of diagnostic methods and treatment modalities, cancer prevention clinical trials, and in vitro studies. Specific services include the following: experimental design, definition of major and secondary endpoints, determination of sample size, development of randomization schemes, database design, database management and quality control, monitoring of side effects and compliance, determination of appropriate statistical tests, consideration of the assumptions underlying statistical procedures, performance of interim and final . analyses, interpretation of statistical results, and preparation of reports, abstracts, manuscripts, grant proposals. Current funding for the Biostatistics Core includes 1.3 FTE provided by the Cancer Center Support Grant. This provides partial support for four persons, Dr McLaren, Dr. Osann, Dr. Taylor, and Ms. Wen-Pin Chen. With institutional support, Ms. Yuhong Huang has joined our group as staff statistician, replacing Mr. Kuo-Tung Li. Additionally, Dr. Daniel L. Gillen, faculty member in the Department of Statistics, provides expertise regarding survival analysis, sequential testing, and interim analyses for clinical trials. These changes have increased our capability to provide service to Cancer Center Members and enable us to continue the tradition in which biostatistical consultation occurs early in protocol development and continues through frequent formal and informal discussions between the investigator and members of the Biostatistics Core. To further expand our capability, we request funds to support Dr. Argyrios Ziogas, Associate Professor, expert in statistical models for analysis of genetic data.

生物统计核心的主要目标是提供支持癌症研究的咨询服务。 生物统计学共享资源的主要活动包括：1）新的统计和设计问题 研究; 2）数据统计分析和咨询; 3）制定临床研究方案。 生物统计研究所参与了包括遗传流行病学在内的各种项目的数据分析 研究;癌症病因学研究;临床研究，以评估生物学标志物，评估诊断 方法和治疗方式，癌症预防临床试验和体外研究。特定服务 包括以下内容：实验设计、主要和次要终点的定义、 样本量、制定随机化方案、数据库设计、数据库管理和质量 控制、监测副作用和依从性，确定适当的统计检验， 考虑统计程序、中期和最终业绩的基本假设。 分析、解释统计结果、编写报告、摘要、手稿、赠款 提案目前生物统计学核心的资金包括癌症中心提供的1.3 FTE 支持格兰特。这为四个人提供了部分支持，他们是麦克拉伦博士、奥桑博士、泰勒博士和凯瑟琳女士。 陈文彬在机构的支持下，黄玉红女士加入了我们的小组，担任统计员， 接替李国栋先生此外，丹尼尔L.吉伦，统计系的教员， 提供生存分析、序贯检验和临床试验中期分析方面的专业知识。 这些变化提高了我们为癌症中心会员提供服务的能力， 延续在方案制定早期进行生物统计学咨询的传统， 继续通过调查员和委员会成员之间频繁的正式和非正式讨论， 生物统计学核心。为了进一步扩大我们的能力，我们要求资金支持Argyrios Ziogas博士， 副教授，遗传数据分析统计模型专家。