BIOSTATISTICS SHARED RESOURCE

生物统计核心的主要目标是为支持癌症研究提供咨询服务。生物统计学共享资源的主要活动包括：1)新研究的统计和设计问题；2)数据统计分析与咨询；3)临床研究方案的制定。BSR参与了各种项目的数据分析，包括遗传流行病学研究；癌症病因学研究；评估生物标志物的临床研究、诊断方法和治疗方式的评估、癌症预防的临床试验和体外研究。具体服务包括：实验设计、确定主要终点和次要终点、确定样本量、制定随机化方案、数据库设计、数据库管理和质量控制、监测副作用和遵守情况、确定适当的统计检验、考虑统计程序的基本假设、执行临时和最终检验。分析、解释统计结果，准备报告、摘要、手稿、奖助金提案。生物统计学核心目前的资金包括由癌症中心支持基金提供的1.3个FTE。这为McLaren博士、Osann博士、Taylor博士和陈文品女士四人提供了部分支持。在机构的支持下，黄玉红女士已加入本集团，接替李国栋先生担任统计人员。此外，统计学系教授Daniel L. Gillen博士提供有关生存分析、序列测试和临床试验中期分析的专业知识。这些变化提高了我们为癌症中心成员提供服务的能力，使我们能够继续在方案制定的早期进行生物统计学咨询，并通过研究者和生物统计学核心成员之间频繁的正式和非正式讨论来继续这一传统。为了进一步扩大我们的能力，我们请求资金支持Argyrios Ziogas博士，副教授，遗传数据分析统计模型专家。

The primary goal of the Biostatistics Core is to provide consulting services in support of cancer research. The primary activities of the Biostatistics Shared Resource include: 1) statistical and design issues for new studies; 2) statistical analysis of data and consultation; and 3) development of clinical research protocols. The BSR has been involved in data analyses in a wide variety of projects, including genetic epidemiology studies; cancer etiology research; clinical studies to evaluate biological markers, assessment of diagnostic methods and treatment modalities, cancer prevention clinical trials, and in vitro studies. Specific services include the following: experimental design, definition of major and secondary endpoints, determination of sample size, development of randomization schemes, database design, database management and quality control, monitoring of side effects and compliance, determination of appropriate statistical tests, consideration of the assumptions underlying statistical procedures, performance of interim and final . analyses, interpretation of statistical results, and preparation of reports, abstracts, manuscripts, grant proposals. Current funding for the Biostatistics Core includes 1.3 FTE provided by the Cancer Center Support Grant. This provides partial support for four persons, Dr McLaren, Dr. Osann, Dr. Taylor, and Ms. Wen-Pin Chen. With institutional support, Ms. Yuhong Huang has joined our group as staff statistician, replacing Mr. Kuo-Tung Li. Additionally, Dr. Daniel L. Gillen, faculty member in the Department of Statistics, provides expertise regarding survival analysis, sequential testing, and interim analyses for clinical trials. These changes have increased our capability to provide service to Cancer Center Members and enable us to continue the tradition in which biostatistical consultation occurs early in protocol development and continues through frequent formal and informal discussions between the investigator and members of the Biostatistics Core. To further expand our capability, we request funds to support Dr. Argyrios Ziogas, Associate Professor, expert in statistical models for analysis of genetic data.