BIOSTATISTICS SHARED RESOURCE

生物统计共享资源

• 批准号: 8740847
• 负责人: Christine E. Mclaren
• 金额: $ 7.28万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-11 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8740847
• 关键词: Adverse effects; Aleurites; Applications Grants; Biological Markers; Biostatistics Core; Biostatistics Shared Resource; Cancer Center; Cancer Center Support Grant; Cancer Etiology; Clinical Research; Clinical Research Protocols; Clinical Trials; Consult; Consultations; Data; Data Analyses; Data Base Management; Development; Diagnostic Procedure; Endpoint Determination; Experimental Designs; Faculty; Funding; Goals; In Vitro; Manuscripts; Modality; Monitor; Performance; Persons; Preparation; Procedures; Quality Control; Randomized; Reporting; Research; Research Personnel; Sample Size; Scheme; Services; Statistical Data Interpretation; Statistical Models; Survival Analysis; Testing; University of California Irvine Cancer Center; abstracting; anticancer research; cancer prevention; database design; design; epidemiology study; genetic analysis; genetic epidemiology; member; prevention clinical trial; professor; protocol development; statistics

The primary goal of the Biostatistics Core is to provide consulting services in support of cancer research. The primary activities of the Biostatistics Shared Resource include: 1) statistical and design issues for new studies; 2) statistical analysis of data and consultation; and 3) development of clinical research protocols. The BSR has been involved in data analyses in a wide variety of projects, including genetic epidemiology studies; cancer etiology research; clinical studies to evaluate biological markers, assessment of diagnostic methods and treatment modalities, cancer prevention clinical trials, and in vitro studies. Specific services include the following: experimental design, definition of major and secondary endpoints, determination of sample size, development of randomization schemes, database design, database management and quality control, monitoring of side effects and compliance, determination of appropriate statistical tests, consideration of the assumptions underlying statistical procedures, performance of interim and final . analyses, interpretation of statistical results, and preparation of reports, abstracts, manuscripts, grant proposals. Current funding for the Biostatistics Core includes 1.3 FTE provided by the Cancer Center Support Grant. This provides partial support for four persons, Dr McLaren, Dr. Osann, Dr. Taylor, and Ms. Wen-Pin Chen. With institutional support, Ms. Yuhong Huang has joined our group as staff statistician, replacing Mr. Kuo-Tung Li. Additionally, Dr. Daniel L. Gillen, faculty member in the Department of Statistics, provides expertise regarding survival analysis, sequential testing, and interim analyses for clinical trials. These changes have increased our capability to provide service to Cancer Center Members and enable us to continue the tradition in which biostatistical consultation occurs early in protocol development and continues through frequent formal and informal discussions between the investigator and members of the Biostatistics Core. To further expand our capability, we request funds to support Dr. Argyrios Ziogas, Associate Professor, expert in statistical models for analysis of genetic data.

生物统计核心的主要目标是提供支持癌症研究的咨询服务。生物统计学共享资源的主要活动包括：1）新研究的统计和设计问题; 2）数据的统计分析和咨询; 3）临床研究方案的制定。BSR参与了各种项目的数据分析，包括遗传流行病学研究;癌症病因学研究;评估生物标志物的临床研究，诊断方法和治疗方式的评估，癌症预防临床试验和体外研究。具体服务包括：实验设计、主要和次要终点的定义、样本量的确定、随机化方案的制定、数据库设计、数据库管理和质量控制、副作用和依从性的监测、适当统计检验的确定、统计程序基础假设的考虑、中期和最终数据的执行。分析、解释统计结果，并准备报告、摘要、手稿、赠款提案。目前生物统计核心的资金包括癌症中心支持补助金提供的1.3 FTE。这为McLaren博士、Osann博士、Taylor博士和Wen-Pin Chen女士四人提供了部分支持。在机构的支持下，Yuhong Huang女士已加入我们的小组，担任统计员，取代李国栋先生。此外，丹尼尔L.吉伦是统计系的教员，提供有关生存分析、序贯测试和临床试验中期分析的专业知识。这些变化提高了我们为癌症中心成员提供服务的能力，使我们能够继续在方案制定早期进行生物统计咨询的传统，并通过研究者与生物统计核心成员之间频繁的正式和非正式讨论继续进行。为了进一步扩大我们的能力，我们要求资金支持Argyrios Ziogas博士，副教授，遗传数据分析统计模型专家。