IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS STUDY

铁超载和遗传性血色素沉着症研究是一项流行病学研究，对铁超载和遗传性血色素沉着症的患病率、遗传和环境决定因素以及潜在的临床、个人和社会影响进行研究，样本为100,000名成年人，调查对象为多中心、多种族、基于初级保健的样本。这些信息将被用来确定以初级保健为基础的铁超载和遗传性血色素沉着症筛查和干预的可行性和潜在的个人和公共健康益处和风险。10万名参与者将从五个外地中心招募进行筛选。筛查后，将对选定的个人进行临床检查。这项研究的最后一个组成部分是一项家庭研究，它将使用基因组扫描和连锁评估来确定与铁超载和遗传性血色素沉着性疾病表达相关的遗传变异。

The Iron Overload and Hereditary Hemochromatosis Study is an epidemiologic study of the prevalence, genetic and environmental determinants, and potential clinical, personal, and societal impact of iron overload and hereditary hemochromatosis in a multi-center, multi-ethnic, primary care-based sample of 100,000 adults. The information will be used to determine the feasibility and potential individual and public health benefits and risks of primary care-based screening and intervention for iron overload and hereditary hemochromatosis. The 100,000 participants will be recruited from five field centers for screening. Following the screening, a clinical examination will be conducted in selected individuals. The final component of the study is a family study which will use genome scanning and assessment of linkage to identify genetic variants related to the expression of iron overload and hereditary hemochromatosis disorders.