CENTER FOR CLINICAL NETWORK FOR ARDS TREATMENT

急性呼吸窘迫综合征(ARDS)临床网络是 作为一项合同计划于1994年建立，遵循国家 竞争。该网络有10个临床中心(由24个 医院)和一个临床协调中心。该网络是 成立的目的是加速开发有效的ARDS治疗方法 以一种严格的、 受控设置。指导委员会，由网络组成 调查人员，选择和制定供审查的方案 一个独立的议定书审查委员会的科学价值。一次 由这个委员会，数据安全和监测委员会批准， 是由重症监护和肺部医学、统计学、 和道德，建议研究所进行这项研究，包括数据 质量和分析、招聘或面临的其他问题 调查人员，以及人类安全问题。电子数据收集 系统和网络调查人员的网站由 协调中心，便于数据管理和 组成ARDS网络的医院之间的通信。 在技术现场访问和审查时，数据质量受到仔细监控。通过 进行仔细的、受控的临床试验，该网络提供 对新疗法和管理进行系统评估的机会 实践，也为复杂的临床研究提供了一种模式 学习。 截至2001年夏季，该网络已完成3个协议，并 指挥其他3人。年秋季又增加了10个中心 2000，以协助一项比较肺动脉导管和 中心静脉导管和两种液体管理策略在治疗中的应用 急性肺损伤和急性呼吸窘迫综合征。已完成的研究有：呼吸系统 急性肺损伤和急性呼吸窘迫综合征的救治 肺损伤和ARDS；利索茶碱治疗急性肺损伤和ARDS。 正在进行的研究包括：晚期类固醇抢救研究； 低潮气量、高呼气末气量疏肺 肺损伤与肺动脉导管/液体管理研究 急性肺损伤和ARDS。

The Acute Respiratory Distress Syndrome (ARDS) Clinical Network was established as a contract program in 1994 following a national competition. The network has ten clinical centers (composed of 24 hospitals) and one clinical coordinating center. The network was established to hasten the development of effective therapy for ARDS by evaluating new treatments and management practices in a rigorous, controlled setting. The Steering Committee, comprised of network investigators, selects and develops protocols that are reviewed for scientific merit by an independent Protocol Review Committee. Once approved by this committee, the Data Safety and Monitoring Board, that is composed of experts in critical care and pulmonary medicine, statistics, and ethics, advises the institute on conduct of the study, including data quality and analysis, recruitment or other issues faced by the investigators, and human safety concerns. An electronic data collection system and a web site for network investigators were established by the coordinating center to facilitate ease of data management and communication between the hospitals that comprise the ARDS Network. Data quality is carefully monitored at technical site visits and reviews. By conducting careful, controlled clinical trials, the network offers the opportunity for systematic evaluation of new therapies and management practices and also offers a model for clinical investigation in complex studies. As of Summer 2001, the network has completed 3 protocols and is conducting 3 others. An additional 10 centers were added in the fall of 2000 to assist in a study comparing the pulmonary artery catheter vs central venous catheter, and two fluid management strategies in treating acute lung injury and ARDS. Completed studies are: Respiratory Management in Acute Lung Injury and ARDS; Ketoconazaole in Acute Lung Injury and ARDS; and Lisofylline in Acute Lung Injury and ARDS. Studies in progess are: The Late Steroid Rescue Study; Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury, and The Pulmonary Artery Catheter/Fluid Management Study in Acute Lung Injury and ARDS.