EXAMINATION OF ALCOHOL AND NICOTINE COADMINISTRATION

在男性中，酒精和尼古丁的共同使用呈正相关，饮酒的人吸烟的可能性增加，反之亦然。 虽然酒精和尼古丁被认为是人类最常见的药物组合之一，但人们对这两种药物之间的关系知之甚少。 拟定的实验将通过研究一种药物自我给药对随后另一种药物自我给药以及两种药物同时给药的影响，检查这些药物在大鼠中的相互作用。 正在检验的假设预测，酒精和尼古丁通过药理学机制相互作用，只有当另一种药物存在时，一种药物的自我给药才会受到影响。 这些实验是独特的，因为大鼠将能够在日常操作期间自我施用尼古丁（静脉内）和酒精（口服）。 使用此程序检查酒精和尼古丁之间的关系将开发一个模型，可用于进一步确定这两种药物之间的相互作用机制。

The co-use of alcohol and nicotine is positively correlated in man, with people who drink alcohol having an increased probability of smoking and vice versa. Although alcohol and nicotine are known to be one of the most common combinations of drugs abused by man, little is known about the relationship between these two drugs. The experiments proposed will examine the interaction between these drugs in rats by investigating the effect of self-administration of one drug on the subsequent self-administration of the other drug as well as the concurrent administration of both. The hypothesis being tested predicts that alcohol and nicotine are interacting by a pharmacological mechanism and that self-administration of one drug will be affected only when the other drug is present. These experiments are unique because the rats will be able to self-administer both nicotine (intravenously) and alcohol (orally) during daily operant sessions. Examination of the relationship between alcohol and nicotine using this procedure will develop a model that can be used for further determination of the mechanism of the interaction between these two drugs.