EXAMINATION OF ALCOHOL AND NICOTINE COADMINISTRATION

酒精和尼古丁联合用药的检查

• 批准号: 6362154
• 负责人: AMANDA L SHARPE
• 金额: $ 3.27万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6362154
• 关键词: behavioral /social science research tag; drug abuse; drug interactions; ethanol; ethology; laboratory rat; nicotine; operant conditionings; self medication; substance abuse related behavior

The co-use of alcohol and nicotine is positively correlated in man, with people who drink alcohol having an increased probability of smoking and vice versa. Although alcohol and nicotine are known to be one of the most common combinations of drugs abused by man, little is known about the relationship between these two drugs. The experiments proposed will examine the interaction between these drugs in rats by investigating the effect of self-administration of one drug on the subsequent self-administration of the other drug as well as the concurrent administration of both. The hypothesis being tested predicts that alcohol and nicotine are interacting by a pharmacological mechanism and that self-administration of one drug will be affected only when the other drug is present. These experiments are unique because the rats will be able to self-administer both nicotine (intravenously) and alcohol (orally) during daily operant sessions. Examination of the relationship between alcohol and nicotine using this procedure will develop a model that can be used for further determination of the mechanism of the interaction between these two drugs.

酒精和尼古丁的共同使用在男性中是正相关的，喝酒的人吸烟的可能性增加，反之亦然。虽然酒精和尼古丁被认为是人类滥用的最常见的药物组合之一，但人们对这两种药物之间的关系知之甚少。提出的实验将通过研究一种药物的自我给药对随后的另一种药物的自我给药以及两种药物同时给药的影响来研究这些药物在大鼠身上的相互作用。正在测试的假设预测酒精和尼古丁通过一种药理学机制相互作用，只有当另一种药物存在时，一种药物的自我服用才会受到影响。这些实验是独一无二的，因为在每天的手术过程中，大鼠将能够自我管理尼古丁（静脉注射）和酒精（口服）。用这种方法研究酒精和尼古丁之间的关系，将建立一个模型，可用于进一步确定这两种药物之间相互作用的机制。