EXAMINATION OF ALCOHOL AND NICOTINE COADMINISTRATION

在男性中，酒精和尼古丁的共同使用是正相关的，饮酒的人吸烟的可能性增加，反之亦然。虽然酒精和尼古丁是人类滥用的最常见的药物组合之一，但人们对这两种药物之间的关系知之甚少。拟议的实验将通过调查一种药物的自我给药对另一种药物随后的自我给药的影响以及两种药物的同时给药来检查这些药物在大鼠身上的相互作用。正在测试的假说预测，酒精和尼古丁是通过药理学机制相互作用的，只有当一种药物存在时，另一种药物的自我给药才会受到影响。这些实验是独一无二的，因为大鼠将能够在每天的手术过程中自我给药尼古丁(静脉注射)和酒精(口服)。用这种方法检查酒精和尼古丁之间的关系将开发出一个模型，可以用来进一步确定这两种药物之间相互作用的机制。

The co-use of alcohol and nicotine is positively correlated in man, with people who drink alcohol having an increased probability of smoking and vice versa. Although alcohol and nicotine are known to be one of the most common combinations of drugs abused by man, little is known about the relationship between these two drugs. The experiments proposed will examine the interaction between these drugs in rats by investigating the effect of self-administration of one drug on the subsequent self-administration of the other drug as well as the concurrent administration of both. The hypothesis being tested predicts that alcohol and nicotine are interacting by a pharmacological mechanism and that self-administration of one drug will be affected only when the other drug is present. These experiments are unique because the rats will be able to self-administer both nicotine (intravenously) and alcohol (orally) during daily operant sessions. Examination of the relationship between alcohol and nicotine using this procedure will develop a model that can be used for further determination of the mechanism of the interaction between these two drugs.