A COMBINED FAMILY AND MULTIVARIATE QTL LINKAGE STUDY OF ATTENTION

该项目的最初目的是研究两种评估方法之间的关系。CBCL（儿童行为检查表）是一种定量工具，它可以对八种行为综合症中的行为进行连续评分：注意力问题、攻击行为、违法行为、行为问题、对立行为、退缩行为、躯体抱怨和思想问题。DSM - IV（诊断与统计手册）是一个将情绪和行为问题概念化为离散障碍的分类系统。例如，这一阶段的研究包括预测CBCL注意问题的异常得分（t得分bbbb67）也表明根据DSM存在注意缺陷多动障碍。事实上，数据显示这种特殊的关系在100%的情况下都是正确的。目前，佛蒙特家庭基因研究的数据收集阶段正在进行中。主要假设预测，与对照组的兄弟姐妹相比，患有CBCL异常综合征/符合DSM诊断的儿童的兄弟姐妹患相同情绪/行为问题的风险更高。潜在的参与者是从儿童、青年和家庭中心或佛蒙特大学大学健康中心儿科诊所的患者中挑选出来的。合格与否取决于至少有一位亲生父母，至少有一位年龄在6 - 18岁之间的全兄妹，患者年龄必须在6 - 18岁之间，并且在CBCL中存在注意力问题、攻击行为、两者都有或两者都没有的异常症状。通过电话联系家长并邀请他们参加。这项研究包括两个部分：完成几份问卷调查，以及一个两小时的访问，在此期间，父母会亲自采访他们孩子的行为，孩子们会接受一系列简短的认知测试，以排除学习障碍或发育迟缓。家长可以选择到弗莱彻艾伦医院的临床研究中心来，也可以接受家访。用于基因测试的唾液是在访问时获得的。本研究的主要意义是发展更准确和有效的诊断方法，以确保早期干预常见的儿童情绪和行为问题。

The initial aim of this project was to examine the relations between two assessment methodologies. The CBCL (Child Behavior Checklist) is a quantitative tool which scores behavior along a continuum within each of eight behavioral syndromes: Attention Problems, Aggressive Behavior, Delinquent Behavior, Conduct Problems, Oppositional Behavior, Withdrawn Behavior, Somatic Complaints, and Thought Problems. The DSM - IV (Diagnostic and Statistical Manual) is a categorical system of conceptualizing emotional and behavioral problems as discrete disorders. For example, this phase of the study included the prediction that a deviant score on Attention Problems of the CBCL (T-score >67) would also indicate the presence of an Attention Deficit Hyperactivity Disorder according to the DSM. In fact, the data showed this particular relationship to be true 100% of the time. Currently, the data collection phase of the Vermont Family Genetic Study is underway. The primary hypothesis predicts siblings of children who are deviant on CBCL syndromes / meet a DSM diagnosis are at increased risk for the same emotional / behavioral problems aompared to siblings of a control group. Potential participants are selected from a pool of patients seen either at the Center for Children Youth and Families or the Pediatric Clinic at the University Health Center, University of Vermont. Eligibility is determined by the availability of at least one biological parent, at least one full sibling between the ages of 6 - 18, age of the patient must be between 6 - 18, and deviance on the Attentional Problems, Aggressive Behavior, both, or neither of these syndromes on the CBCL. Parents are contacted by telephone and invited to participate. The study consists of two parts: completing several questionnaires, and a two hour visit during which parents are interviewed in person about their children's behavior, and children are administered a brief battery of cognitive tests in order to rule out learning disabilities or developmental delay. Parents are given the option of coming in to the Clinical Research Center at Fletcher Allen Hospital or be provided with a home visit. Saliva for genetic testing is obtained at the time of the visit. The main implication of this study is to develop more accurate and efficient diagnostic methodology to ensure early intervention of common childhood emotional and behavioral problems.