A COMBINED FAMILY AND MULTIVARIATE QTL LINKAGE STUDY OF ATTENTION

这个项目的最初目的是检查两者之间的关系 评估方法。CBCL(儿童行为检查表)是一种 一种量化工具，用于对每一项中的行为进行连续评分 八种行为综合症：注意力问题，攻击行为， 违法行为、行为问题、反对行为、退缩 行为、躯体抱怨和思维问题。DSM-IV( 《诊断和统计手册》)是一个分类系统 将情绪和行为问题概念化为离散的障碍。 例如，这一阶段的研究包括预测 CBCL在注意力问题上的偏差分数(T-Score&gt；67)也会 表明存在注意力缺陷多动障碍 根据DSM的说法。事实上，数据显示了这一点 关系100%为真。目前，数据收集 佛蒙特州家族遗传学研究的阶段正在进行中。初级阶段 假说预测CBCL综合征异常儿童的兄弟姐妹 /符合DSM诊断的人患相同情绪障碍的风险增加/ 行为问题比对照组的兄弟姐妹更多。潜在的 参与者是从一群患者中挑选出来的，这些患者要么在 儿童、青年和家庭中心或儿科诊所 佛蒙特州大学健康中心。资格已确定 至少有一位亲生父母，至少一位完整的 6-18岁的兄弟姐妹，患者的年龄必须在6-18岁之间， 注意力问题、攻击性行为上的偏差，或者 CBCL上的这两种症状都不是。通过电话联系父母 并被邀请参加。本研究由两部分组成：完成 几份问卷，以及两个小时的访问，在此期间，父母 当面采访他们孩子的行为，孩子们 进行了一系列简短的认知测试，以排除 学习障碍或发育迟缓。父母被给予了 选择进入弗莱彻·艾伦临床研究中心 医院或为其提供家访服务。用于基因检测的唾液是 在访问时获得。数据是以这种方式收集的 从07/96开始。到目前为止，已有75个家庭参加。我们的目标是 每周安排并采访4个家庭，至少再坚持一年。 这项研究的主要含义是开发更准确和高效的 确保对普通儿童进行早期干预的诊断方法 情绪和行为问题。

The initial aim of this project was to examine the relations between two assessment methodologies. The CBCL (Child Behavior Checklist) is a quantitative tool which scores behavior along a continuum within each of eight behavioral syndromes: Attention Problems, Aggressive Behavior, Delinquent Behavior, Conduct Problems, Oppositional Behavior, Withdrawn Behavior, Somatic Complaints, and Thought Problems. The DSM- IV ( Diagnostic and Statistical Manual) is a categorical system of conceptualizing emotional and behavioral problems as discrete disorders. For example, this phase of the study included the prediction that a deviant score on Attention Problems of the CBCL ( T-score > 67) would also indicate the presence of an Attention Deficit Hyperactivity Disorder according to the DSM. In fact, the data showed this particular relationship to be true 100% of the time.Currently, the data collection phase of the Vermont Family Genetic Study is underway. The primary hypothesis predicts siblings of children who are deviant on CBCL syndromes / meet a DSM diagnosis are at increased risk for the same emotional / behavioral problems than siblings of a control group.Potential participants are selected from a pool of patients seen either at the Center for Children Youth and Families or the Pediatric Clinic at the University Health Center, University of Vermont. Eligibility is determined by the availability of at least one biological parent, at least one full sibling between the ages of 6-18, age of the patient must be between 6-18, and deviance on the Attention Problems, Aggressive Behavior, both, or neither of these syndromes on the CBCL. Parents are contacted by telephone and invited to participate. The study consists of two parts: completing several questionnaires, and a two hour visit during which parents are interviewed in person about their children's behavior, and children are administered a brief battery of cognitive tests in order to rule out learning disabilities or developmental delay. Parents are given the option of coming in to the Clinical Research Center at Fletcher Allen Hospital or be provided with a home visit. Saliva for genetic testing is obtained at the time of the visit.Data has been collected in this manner since 07/96. To date 75 families have participated. The goal is to schedule and interview 4 families a week for at least another year.The main implication if this study is to develop more accurate and efficient diagnostic methodology to ensure early intervention of common childhood emotional and behavioral problems.