APOMORPHINE CHALLENGE IN SCHIZOPHRENIA & NORMALS

精神分裂症(SCH)患者血浆促肾上腺皮质激素和皮质醇对阿朴吗啡的反应明显减弱。血浆高香草酸水平与基础皮质醇水平呈正相关，与APO刺激的ACTH和皮质醇反应呈负相关。氯氮平和奥氮平可增强血浆ACTH和皮质醇对APO的反应，降低Sch的PHVA水平。氯氮平或奥氮平治疗后血浆ACTH和皮质醇对APO反应的变化或PHVA水平的下降或两者均可预测对氯氮平或奥氮平的临床反应。

Plasma adrenocorticotropin hormone and cortisol responses to apmorphine are significantly blunted in patients with schizophrenia (SCH) compared to normal controls. Plasma homovanillic acid levels are positively correlated with basal cortisol levels and inversely correlated with APO-stimulated ACTH and cortisol response in SCH. Chronicc treatment with clozapine and olanzapine enhances the plasma ACTH and cortisol responses to APO and decreases pHVA levels in SCH. The change in the plasma ACTH and cortisol responses to APO or the decrease in pHVA levels, or both, after treatment with clozapine or olanzapine predicts clinical response to clozapine or olanzapine.