CORRELATION OF THYMIDYLATE SYNTHASE IN 5-FU TREATED COLORECTAL CANCER

胸苷酸合酶与 5-FU 治疗结直肠癌的相关性

• 批准号: 6115738
• 负责人: HOWARD S HOCHSTER
• 金额: $ 2.1万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115738
• 关键词: 5 fluorouridine; antineoplastics; clinical research; clinical trials; colorectal neoplasms; combination chemotherapy; human subject; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; polymerase chain reaction; thymidylate synthase

This is a randomized trial of two different methods of administering 5-FU plus leukovorin in the treatment of colon cancer. Samples of the tumor will be assayed for thymidylate synthase (TS) message by RT-PCR, following which the patients will be randomized to receive intermittent high dose 5-FU infusion or continuous low dose infusion. Patients will continue to receive the same therapy until either toxicity or poor response occurs. Response will be correlated with apparent TS levels.

这是一项随机试验，研究了两种不同的5-FU加leukovorin治疗结肠癌的方法。 将通过RT-PCR测定肿瘤样品的胸苷酸合成酶（TS）信息，随后将患者随机分配接受间歇性高剂量5-FU输注或连续低剂量输注。 患者将继续接受相同的治疗，直到出现毒性或不良反应。反应将与表观TS水平相关。