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EVALUATE EFFECT OF INTRANASALLY ADMINISTERED INTERLEUKINS

EVALUATE EFFECT OF INTRANASALLY ADMINISTERED INTERLEUKINS
评估鼻内给药白细胞介素的效果
批准号：
6264547
负责人：
DAVID P SKONER
金额：
$1.63万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264547
关键词：
clinical research clinical trial phase I drug screening /evaluation human subject human therapy evaluation inhalation drug administration interleukin 1 interleukin 10 interleukin 6 interleukin 8 outcomes research respiratory disorder chemotherapy respiratory disorder epidemiology respiratory hypersensitivity respiratory reflex secretion sign /symptom

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中文摘要
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英文摘要
To determine if topical, intranasal administration of Il-1B, Il-6, IL-8 or Il-10 alters nasal symptomatology and/or physiology. Non-allergic, asymptomatic allergic and symptomatic allergic subjects will be studied since these cytokines may produce differntial effects in these groups. Primary outcomes include nasal resistance, sneeze and cough counts, nasal secretion weights and nasal and throat symptom scores.
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