ASTHMA AND STRESS

哮喘和压力

• 批准号: 6276752
• 负责人: DAVID P SKONER
• 金额: $ 1.51万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276752
• 关键词: asthma; bronchoconstrictors; clinical research; drug screening /evaluation; human subject; human therapy evaluation; methacholine; respiratory airway volume; respiratory function; stress

It is commonly believed that stressful life events make people more susceptible to asthmatic events. We propose a within subject design where volunteers are administered a bronchoconstrictor challenge once under relatively stressful conditions, once under relatively calm conditions, and once during a neutral period. The challenge will involve determining a dose-response curve for the effects, of the bronchoconstrictor on lung funciton as measured by FEV1. Volunteers will be randomly assigned to condition order (stress then calm or calm then stress). We will use methacoline as the bronchoconstrictor.

人们普遍认为，有压力的生活事件会让人 易患哮喘的易患哮喘的我们提出了一种主题内设计，其中 志愿者在下一次呼吸困难时接受支气管收缩试验 压力比较大的情况，一旦在比较平静的情况下， 还有一次是在中立期。挑战将涉及确定 支气管收缩药对肺影响的剂量-反应曲线 FEV1测定功能。志愿者将被随机分配到 状态顺序(先是压力，然后是平静或平静，然后是压力)。我们将使用 乙酰甲胆碱作为支气管束缩窄剂。