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MULTIPLE DOSE SAFETY STUDY OF MOMETASONE FUROATE DRY POWDER IN ASTHMATIC CHILD

MULTIPLE DOSE SAFETY STUDY OF MOMETASONE FUROATE DRY POWDER IN ASTHMATIC CHILD
糠酸莫米松干粉多剂量治疗哮喘儿童的安全性研究
批准号：
6115537
负责人：
DAVID P SKONER
金额：
$2.06万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6115537
关键词：
antiinflammatory agents asthma child (0-11) clinical research clinical trial phase I cortisol dosage dosage forms drug screening /evaluation glucocorticoids human subject human therapy evaluation hypothalamic pituitary adrenal axis inhalation drug administration pediatric pharmacology respiratory disorder chemotherapy

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中文摘要
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英文摘要
A multiple dose safety study that is part of a clinical program designed to fully evaluate the efficacy and safety of mometasone furoate dry powder inhaler (MFDPI) in children for the indication of asthma. The objective of this study was to determine the systemic effects of MFDPI lactose-mix (100, 200, or 400 mcg bid) on HPA-axis function as assessed by 12 hour multiple nocturnal plasma cortisol measurements, cosyntropin stimulation and 24 hour free urinary cortisol concentrations.
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MULTIPLE DOSE SAFETY STUDY OF MOMETASONE FUROATE DRY POWDER IN ASTHMATIC CHILD
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