Disorders of Sex Development: Genetics, Diagnosis, Informing Clinical Care

性发育障碍(DSD)令人惊讶地常见，并经常导致生殖器异常、性别错配、不孕和心理创伤。我们将汇集我们在人类遗传学、分子和发育生物学方面的专业知识，寻找对性发育至关重要的基因，识别导致DSD的基因缺陷，并研究它们的功能。我们将与临床医生联系，将这些结果应用于儿童DSD的准确诊断和医疗护理。

Disorders of sexual development (DSDs) are surprisingly common, and often result in genital abnormalities, gender mis-assignment, infertility and psychological trauma. We will pool our expertise in human genetics, molecular and developmental biology, to find genes important for sex development, identify gene defects that cause DSD, and study their functions. We will liaise with clinicians to apply these findings to the accurate diagnosis and medical care of DSD in children.