CHEMOPREVENTION OF COLON NEOPLASM WITH VITAMIN D AND CALCIUM

用维生素 D 和钙化学预防结肠肿瘤

• 批准号: 6220045
• 负责人: PETER R HOLT
• 金额: $ 0.04万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220045
• 关键词: 1,25 dihydroxycholecalciferol; adenomatous polyps; biomarker; calcium carbonate; cancer prevention; chemoprevention; cholecalciferol; clinical research; colon neoplasms; human subject; human therapy evaluation; neoplasm /cancer nutrition therapy; vitamin D; vitamin therapy

The study aims to determine whether vitamin D3 or/and the active metabolite 1,25 hydroxy vitamin D alters biomarkers that have been shown to be associated with adenomatous polyposis and therefore, the risk for colon cancer. The results will be compared to that obtained by administration of calcium carbonate, which is known to improve biomarkers of colon neoplasia in adenomoatous polyp patients.

这项研究旨在确定维生素D3或/和活性代谢物1，25羟基维生素D是否会改变已被证明与腺瘤性息肉病相关的生物标记物，从而增加结肠癌的风险。研究结果将与服用碳酸钙的结果进行比较，碳酸钙被认为可以改善腺瘤性息肉患者结肠肿瘤的生物标志物。