EXOCYCLIC ADDUCTS--SITE-SPECIFIC MUTAGENESIS
外环加合物——位点特异性诱变
基本信息
- 批准号:6269371
- 负责人:
- 金额:$ 19.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-03-10 至 1999-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objectives of this research are to determine the mutational spectra of
lesions produced in mammalian cells and bacteria when exocyclic adducts are
introduced at specific genomic sites and to delineate recombinational
events as they relate to mutagenesis produced by such adducts.
DNA adducts may be removed by the concerted action of repair enzymes acting
throughout the genome. When this process is incomplete, the stage is set
for errors in DNA replication that lead to mutation. We intend to inves-
tigate several aspects of DNA repair as it relates to the structure and
function of exocyclic adducts.
We have developed experimental systems, using SV40-based shuttle plasmid
vectors, by which the mutagenic spectra of selected DNA adducts can be
determined. This approach allows us to examine the sequence specificity of
mutational reactions with particular reference to "hot spots" and proto-
oncogenes. Using these systems, which reflect forward mutagenic events
produced by a single species of DNA adduct and by correlating our studies
with the results of molecular modeling and 2D-NMR experiments, we hope to
define structure-activity relationships that will assist in elucidating
mechanisms of chemical mutagenesis and, possibly, predict mutagenic effects
for certain classes of chemical carcinogens.
本研究的目的是确定突变谱
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Arthur Patrick Grollman其他文献
Arthur Patrick Grollman的其他文献
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{{ truncateString('Arthur Patrick Grollman', 18)}}的其他基金
PROJECT 3- TOXICOGENOMICS ARISTOLOCHIC ACID NEPHROPATHY
项目 3 - 毒理学马兜铃酸肾病
- 批准号:
8069937 - 财政年份:2010
- 资助金额:
$ 19.17万 - 项目类别:
PROJECT 3- TOXICOGENOMICS ARISTOLOCHIC ACID NEPHROPATHY
项目 3 - 毒理学马兜铃酸肾病
- 批准号:
7305793 - 财政年份:2007
- 资助金额:
$ 19.17万 - 项目类别:
Molecular Pharmacology of Tumor and Virus Inhibitors
肿瘤和病毒抑制剂的分子药理学
- 批准号:
6894590 - 财政年份:2004
- 资助金额:
$ 19.17万 - 项目类别:
Mutagenic and Repair Mechanisms of Endogenous DNA Damage
内源性DNA损伤的诱变与修复机制
- 批准号:
6990324 - 财政年份:2004
- 资助金额:
$ 19.17万 - 项目类别:
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