ORAL MANIFESTATIONS OF PEDIATRIC HIV

儿童艾滋病毒的口腔表现

• 批准号: 6104838
• 负责人: DOUGLAS H FINE
• 金额: $ 41.69万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6104838
• 关键词: biomarker; blood chemistry; candidiasis; child (0-11); dental caries; disease /disorder proneness /risk; epidemiology; gingivitis; human subject; oral health; pediatric AIDS; periodontium disorder; preventive dentistry; prognosis; siblings; therapy compliance

Evidence exists to suggest that oral manifestations are markers of HIV- disease progression in children and may have the potential for prognostic value independent of other commonly used markers such as CD4 counts. In addition, the oral manifestations of HIV infection in children are different from those found in adults. For these reasons, it is important to study the oral manifestations of HIV infection in children. Several important observations on the oral manifestations of HIV infection in children were made during the preliminary studies of the Phase 1 funding period of the NMOHRC, including: 1-confirmation of the high levels of dental caries, pain and other soft tissue pathology; 2-documentation of a high level of untreated oral disease and poor compliance with recommendations for oral health care; 3-confirmation of previous reports of high levels of putative pathogens in the microflora of pediatric HIV infected patients; 4- the dissociation of bacterial colonization with clinical evidence of disease; and, 5- the observation of moderate levels of periodontopathic bacteria in the oral cavity of HIV negative coinhabitants of pediatric HIV infected patients. These observations are the basis for studies and interventions planned for the next 5 years of the NM0HRC. These studies will achieve the following Specific Aims: 1-To determine the risk factors for increased dental caries in HIV positive children compared to HIV negative children; 2-To investigate factors which may be associated with poor compliance with dental care recommendations for HlV infected children; 3- To determine the prevalence of gingivitis, periodontal disease, oral candidiasis, infection with selected periodontal pathogens, pain and other oral pathology in HIV infected children and HIV negative siblings; and 4- To correlate relevant blood laboratory values, clinical status and medications in the HIV positive subjects with clinical observations related to dental caries, gingivitis, periodontal disease and other oral pathology. The goals of these studies are to better understand the etiology, prevention, treatment and prognostic value of the oral manifestations of HIV infection in children.

有证据表明，口腔表现是艾滋病毒的标志- 儿童疾病进展，并可能有可能预后 值独立于其他常用的标志物，如CD 4计数。在 此外，儿童艾滋病毒感染的口腔表现是 与成年人不同。由于这些原因， 研究儿童感染艾滋病毒的口腔表现。几 艾滋病毒感染的口腔表现的重要观察， 在第一阶段资金的初步研究期间， 1.确认国家人权事务委员会的高级别 龋齿、疼痛和其他软组织病理学; 2-记录 未经治疗的口腔疾病水平高， 口腔保健建议; 3-确认以前的报告 在儿科HIV的微生物区系中存在高水平的假定病原体 感染患者; 4-分离细菌定植， 疾病的临床证据;以及，5-观察到中度水平 牙周病细菌在口腔中的HIV阴性 儿童艾滋病病毒感染者的共同居住者。这些观察结果 为今后五年的研究和干预计划奠定基础， NM0HRC。这些研究将实现以下具体目标： 确定艾滋病毒阳性者龋齿增加的危险因素 与艾滋病毒阴性儿童相比; 2-调查 可能与对牙科护理建议的依从性差有关 对于HIV感染的儿童; 3-确定牙龈炎的患病率， 牙周病，口腔念珠菌病，选择性牙周炎 艾滋病毒感染儿童的病原体、疼痛和其他口腔病理以及艾滋病毒 阴性同胞;和4-关联相关血液实验室值， HIV阳性受试者的临床状态和药物治疗 与龋齿、牙龈炎、牙周病和 其他口腔病理学这些研究的目的是为了更好地理解 口腔黏膜下炎的病因、预防、治疗及预后价值 艾滋病毒感染的儿童的表现。