ORAL MANIFESTATIONS OF PEDIATRIC HIV

儿童艾滋病毒的口腔表现

• 批准号: 6352849
• 负责人: DOUGLAS H FINE
• 金额: $ 52.15万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6352849
• 关键词: biomarker; blood chemistry; candidiasis; child (0-11); dental caries; disease /disorder proneness /risk; epidemiology; gingivitis; human subject; oral health; pediatric AIDS; periodontium disorder; preventive dentistry; prognosis; siblings; therapy compliance

Evidence exists to suggest that oral manifestations are markers of HIV- disease progression in children and may have the potential for prognostic value independent of other commonly used markers such as CD4 counts. In addition, the oral manifestations of HIV infection in children are different from those found in adults. For these reasons, it is important to study the oral manifestations of HIV infection in children. Several important observations on the oral manifestations of HIV infection in children were made during the preliminary studies of the Phase 1 funding period of the NMOHRC, including: 1-confirmation of the high levels of dental caries, pain and other soft tissue pathology; 2-documentation of a high level of untreated oral disease and poor compliance with recommendations for oral health care; 3-confirmation of previous reports of high levels of putative pathogens in the microflora of pediatric HIV infected patients; 4- the dissociation of bacterial colonization with clinical evidence of disease; and, 5- the observation of moderate levels of periodontopathic bacteria in the oral cavity of HIV negative coinhabitants of pediatric HIV infected patients. These observations are the basis for studies and interventions planned for the next 5 years of the NM0HRC. These studies will achieve the following Specific Aims: 1-To determine the risk factors for increased dental caries in HIV positive children compared to HIV negative children; 2-To investigate factors which may be associated with poor compliance with dental care recommendations for HlV infected children; 3- To determine the prevalence of gingivitis, periodontal disease, oral candidiasis, infection with selected periodontal pathogens, pain and other oral pathology in HIV infected children and HIV negative siblings; and 4- To correlate relevant blood laboratory values, clinical status and medications in the HIV positive subjects with clinical observations related to dental caries, gingivitis, periodontal disease and other oral pathology. The goals of these studies are to better understand the etiology, prevention, treatment and prognostic value of the oral manifestations of HIV infection in children.

有证据表明口腔表现是艾滋病毒的标志 儿童疾病进展并可能具有预测预后的潜力 值独立于其他常用标记（例如 CD4 计数）。在 此外，儿童感染艾滋病毒的口腔表现有 与成人中发现的不同。由于这些原因，重要的是 研究儿童艾滋病毒感染的口腔表现。一些 HIV感染者口腔表现的重要观察 第一阶段资助的初步研究期间生下了孩子 NMOHRC 期间，包括： 1-确认高水平 龋齿、疼痛和其他软组织病理学； 2-文档 未经治疗的口腔疾病比例高且依从性差 口腔保健建议； 3-先前报告的确认 儿科艾滋病毒微生物区系中推定病原体的高水平 受感染的病人； 4- 细菌定植的解离 疾病的临床证据；以及，5- 中等水平的观察 HIV 阴性者口腔内牙周病细菌的数量 儿童艾滋病毒感染者的共同居住者。这些观察结果是 未来 5 年计划的研究和干预措施的基础 NM0HRC。这些研究将实现以下具体目标： 1-To 确定艾滋病毒阳性者龋齿增加的危险因素 儿童与艾滋病毒阴性儿童相比； 2-调查因素 可能与不遵守牙科护理建议有关 对于感染艾滋病毒的儿童； 3- 确定牙龈炎的患病率， 牙周病、口腔念珠菌病、特定牙周病感染 HIV 感染儿童的病原体、疼痛和其他口腔病理以及 HIV 消极的兄弟姐妹； 4- 关联相关的血液实验室值， HIV阳性受试者的临床状况和药物治疗 与龋齿、牙龈炎、牙周病相关的观察结果 其他口腔病理。这些研究的目标是更好地了解 口腔溃疡的病因、预防、治疗和预后价值 儿童感染艾滋病毒的表现。