BEHAVIORAL AND ELECTROPHYSIOLOGICAL ASSESSMENT IN HUMANS

人类行为和电生理评估

• 批准号: 6270150
• 负责人: JOHN H MILLS
• 金额: $ 17.62万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6270150
• 关键词: aging; audiometry; auditory discrimination; behavior test; behavioral /social science research tag; binaural hearing; clinical research; electrophysiology; hearing; human subject; psychoacoustics; sound frequency

The long term of Project 1 is to provide the the scientific basis of age- related changes in auditory behavior (presbyacusis) of human subjects. Whereas most studies of presbyacusis use monaural signals in relatively simple psychophysical tasks, the proposed research uses monaural and binaural signals in both psychophysical and electrophysiologic experiments. The auditory signals and listening tasks are selected to challenge the limits of the auditory system to process auditory information. There are three specific aims. Aim 1.1 is the psychophysical assessment of frequency, intensity, and duration discrimination of the aging, binaural auditory system of human subjects. The experiments included under Aim 1.1 and 1.2 (below) are driven by the hypothesis that age-related deficits in auditory behavior, which are assessed monaurally and which are independent of losses of auditory sensitivity, are magnified when assessed under more rigorous conditions such as in binaural hearing. Aim 1.2 is the electrophysiologic assessment of the aging, binaural auditory system of human subjects. The focus is on electrophysiologic correlates of binaural hearing, and intensity discrimination. Aim 1.3 is the electrophysiologic assessment of the temporal resolving power of the aging auditory system of human subjects. The hypothesis is that decreases in temporal coding in aging subjects are due to abnormal processing in the auditory central nervous system. In addition to describing the basic properties of age-related hearing loss, results of the proposed research should identify and assess age-related effects due to the auditory periphery, age-related effects due to the auditory central nervous system, and interactions between the periphery and the central nervous system. These results will provide improvements in diagnosis, treatment, and management of age-related hearing loss in humans.

项目1的长期是提供年龄的科学基础 - 人类受试者听觉行为（长期）的相关变化。 而大多数对长老会的研究都在相对使用的单膜信号 简单的心理物理任务，拟议的研究使用了单声道和 心理物理和电生理学的双耳信号 实验。 听觉信号和听力任务被选择为 挑战听觉系统的限制来处理听觉 信息。 有三个特定的目标。 目标1.1是 频率，强度和持续时间的心理物理评估 对人类受试者的衰老，双耳听觉系统的歧视。 AIM 1.1和1.2（下）中包括的实验由 假设听觉行为中与年龄相关的缺陷， 单核评估，与听觉的损失无关 在更严格的条件下评估时，灵敏度会放大 例如在双耳听证中。 AIM 1.2是电生理学 评估人类受试者的衰老，双耳听觉系统。 这 重点是双耳听力的电生理相关性，以及 强度歧视。 AIM 1.3是电生理评估 人类老化听觉系统的时间解决力 主题。 假设是衰老的时间编码减少 受试者是由于听觉中心神经中的异常处理 系统。 除了描述与年龄有关的基本特性 听力损失，拟议研究的结果应识别和评估 与年龄相关的效果是由于外围，与年龄相关的效果而引起的 由于听觉中枢神经系统以及 周围和中枢神经系统。 这些结果将提供 改善与年龄有关的诊断，治疗和管理 人类的听力损失。