EXPERIMENTAL AND CLINICAL STUDIES OF PRESBYACUSIS

老年痴呆症的实验和临床研究

• 批准号: 3107849
• 负责人: JOHN H MILLS
• 金额: $ 78.13万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3107849
• 关键词: aging; noise induced deafness; presbycusis

This project is concerned with hearing loss associated with aging and with exposure to low levels of noise. Five projects are planned. Project #1 proposes to develop an animal model of presbyacusis and to study hypothesized interactions between aging effects and exposure to noise. Project #2 is a clinical study of human presbyacusis and control subjects with the major purpose being to categorize or develop profiles of presbyacusis that are based on current audiological-otological-medical information. Project #3 addresses the pathophysiology of presbyacusis by examining the physiology of the endolymphatic duct, and the neurophysiology of the auditory nerve and brainstem. Project #4 focuses on the histopathology of the cochlea, particularly the sensory and supporting cells, stria vascularis, and spiral ligament, including vasculature. Project #5 is a histochemical study of the cochlea which extends Project #4 by providing precise information about the presence and distribution of specific molecular constituents in the cochlea. Experimental animals are Mongolian gerbils who are born are born and reared in a quiet, acoustically controlled environment. Project #1 provides experimental animals for Projects 3, 4, and 5. Thus, a given animal is studied with respect to cochlear physiology, neurophysiology of the auditory nerve and brainstem, and cochlear histopathology and histochemistry. These extensive animal data in combination with clinical and experimental data from the humans of Project #2 provide a comprehensive program of research on presbyacusis and hearing loss in general.

该项目与与衰老相关的听力损失有关 并暴露于噪音较低的情况下。 五个项目是 计划。 项目＃1提议开发一种动物模型 长老会并研究假设的相互作用 老化的影响和暴露于噪声。 项目2是临床 研究人类长老会和主要的对照对象 目的是分类或开发长老会的概况 基于当前的听力学医学 信息。 项目＃3解决了 长老会通过检查内淋巴的生理学 导管，以及听觉神经的神经生理学 脑干。 项目＃4侧重于 耳蜗，尤其是感觉和支持细胞，质谱 血管和螺旋韧带，包括脉管系统。 项目 ＃5是对耳蜗的组织化学研究，该研究扩展了项目 ＃4通过提供有关存在和的精确信息 耳蜗中特定分子成分的分布。 实验动物是出生的蒙古沙鼠 在一个安静，声学控制的环境中出生和饲养。 项目1为项目3、4和 5。因此，研究给定的动物有关人工耳蜗 生理学，听觉神经和脑干的神经生理学， 以及人工耳蜗组织病理学和组织化学。 这些广泛 动物数据与临床和实验数据结合 来自项目2的人类提供了一个全面的程序 关于长老会和听力损失的研究。