EXPERIMENTAL AND CLINICAL STUDIES OF PRESBYACUSIS

老年痴呆症的实验和临床研究

• 批准号: 6379257
• 负责人: JOHN H MILLS
• 金额: $ 115.34万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379257
• 关键词: aging; presbycusis

The focus of this research is age-related hearing loss (presbyacusis). Currently, nearly 28 million Americans have impaired hearing, and approximately 75% of these persons are over the age of 55. The prevalence of presbyacusis will increase substantially by the year 2020. To meet the challenges of this most prevalent handicapping condition, new information, diagnostic methods, rehabilitation procedures, and cost-effective access to new technologies will be of great importance. Prevention of presbyacusis and/or a reduction in its prevalence are even greater challenges. The overall objective of our research program is to improve diagnostic, rehabilitive, and preventive measures. Towards this objective, four research projects are proposed. Project 1 is a study of the basic psychophysical and electrophysiological properties of the aging auditory system of human subjects. Project 2 addresses basic questions related to the understanding of speech in realistic listening environments by young and older human subjects with normal and impaired hearing. Project 3 focuses on morphologic and molecular changes in the aging cochlea of gerbil and human subjects. Project 4 investigates neurotrophins and their role in regulating the survival of adult auditory and vestibular neurons using both gerbil and human tissue. In addition, three cores provide administrative, technical,, and scientific support including the procurement and maintenance of laboratory animals, recruitment of human subjects, and retrieval of human tissues. The proposed program of research of presbyacusis in the long term will influence health care of the presbyacusic patient, will affect care of hearing impaired persons in general, and will have significant impact on theoretical issues in the science of audition.

这项研究的重点是与年龄相关的听力损失（Persbyacusis）。 目前，近2800万美国人的听力受损， 这些人中约有75％的年龄超过55岁。 长老会的患病率将在一年中大幅增长 2020年。要应对这种最普遍的残障的挑战 病情，新信息，诊断方法，康复 程序，以及对新技术的具有成本效益的访问 非常重视。 预防长老会和/或减少 它的普遍性是更大的挑战。 总体目标 我们的研究计划是为了改善诊断，康复和 预防措施。 朝向这个目标，四个研究项目 提出了。 项目1是对基本心理物理和 人类老化听觉系统的电生理特性 主题。 项目2解决了与 在年轻的聆听环境中对言语的理解 和年龄较大的人类受试者的听力正常和受损。 项目 3侧重于衰老耳蜗的形态学和分子变化 沙鼠和人类受试者。 项目4研究神经营养蛋白 以及它们在调节成人听觉生存和的作用 使用沙鼠和人体组织的前庭神经元。 另外， 三个核心提供行政，技术和科学支持 包括实验动物的采购和维护， 人类受试者的招募和人类组织的检索。 这 从长远来看，拟议的长老会研究计划将 影响长老会患者的医疗保健，将影响 听力受损的人一般会产生重大影响 关于试镜科学的理论问题。