Dissecting the interactions of antimalarial drugs with the two key determinants of drug resistance in the malaria parasite - the 'chloroquine resistance transporter' and the 'multidrug resistance transporter 1'

剖析抗疟药物与疟原虫耐药性的两个关键决定因素（“氯喹耐药性转运蛋白”和“多药耐药性转运蛋白 1”）之间的相互作用

• 批准号: nhmrc : 1053082
• 负责人: Dr Rowena Martin
• 金额: $ 27.69万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-interactions-antimalarial-transporter-1/112312
• 关键词: Dissecting; interactions; antimalarial; drugs; two

The malaria parasite is a single-celled organism which invades the red blood cells of its host. The aim of this fellowship is to study two proteins that are central to the parasite’s ability to evade the toxic effects of a number of drugs. The parasite's susceptibility to chloroquine, and other drugs, is altered by small changes in these proteins. This work will advance our understanding of the increasingly widespread phenomenon of antimalarial drug resistance, and of how it may be overcome.

疟疾寄生虫是一种单细胞生物，它侵入宿主的红细胞。这项研究的目的是研究两种蛋白质，这两种蛋白质对寄生虫逃避许多药物的毒性作用的能力至关重要。这种寄生虫对氯喹和其他药物的敏感性会因这些蛋白质的微小变化而改变。这项工作将促进我们对日益普遍的抗疟疾药物耐药性现象的理解，以及如何克服这一现象。