Interactions between the malaria parasite's chloroquine resistance transporter and antimalarial drugs

疟疾寄生虫的氯喹抗性转运蛋白与抗疟药物之间的相互作用

• 批准号: nhmrc : 1007035
• 负责人: Dr Rowena Martin
• 金额: $ 32.38万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interactions-malaria-parasites-antimalarial-drugs/109215
• 关键词: Interactions; between; malaria; parasite; chloroquine

The malaria parasite is a single-celled organism which invades the red blood cells of its host. The aim of this project is to characterize the parasite protein responsible for conferring resistance to chloroquine, and to study its interaction with other antimalarial drugs. The parasite's susceptibility to chloroquine, and other drugs, is altered by small changes in this protein. This work will advance our understanding of the increasingly widespread phenomenon of antimalarial drug resistance.

疟疾寄生虫是一种单细胞有机体，它入侵宿主的红细胞。该项目的目的是确定导致氯喹耐药性的寄生虫蛋白的特征，并研究其与其他抗疟疾药物的相互作用。这种寄生虫对氯喹和其他药物的敏感性，会通过这种蛋白质的微小变化而改变。这项工作将增进我们对日益普遍的抗疟药耐药现象的理解。