HEARING IMPAIRMENT AND CONGENITAL CMV IN YOUNG CHILDREN

幼儿听力障碍和先天性巨细胞病毒

• 批准号: 6274041
• 负责人: KAREN B FOWLER
• 金额: $ 2.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-26 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274041
• 关键词: age difference; clinical research; congenital infection; cytomegalovirus; disease /disorder proneness /risk; epidemiology; hearing tests; human subject; infant human (0-1 year); pathologic process; preschool child (1-5); sensorineural hearing loss

The primary objective of this project is to determine the prevalence and the ages when progressive and/or delayed onset of sensorineural hearing loss (SNHL) is most likely to occur in infants and young children due to congenital cytomegalovirus (CMV) infection. Our project is also defining risk factors in the newborn period that predict SNHL in CMV infected infants without clinically apparent disease. Our third aim defines the relative contribution of CMV infection to delayed onset hearing loss in the population. These aims are being achieved by identifying all newborns with congenital CMV infection from University Hospital and serially testing them to evaluate their hearing sensitivity at various ages. Also, a selected control group of newborns who are CMV negative ar being followed and compared to CMV positive children without hearing loss at birth. All infants born at University Hospital are currently screened virologically for congenital CMV infection by the investigators of this proposal. At 3 weeks, 3, 6, 9 and 12 months of age, each CMV positive infant has a complete audiological evaluation by a clinical audiologist that includes an auditory brainstem evoked response (ABR) and immittance measures for each ear. Also, each child has a complete audiological evaluation at 18, 24, and 30 months of age that includes behavioral audiometric assessment (visual reinforcement or play audiometry) and immittance measures to obtain pure tone thresholds, speech reception thresholds and speech discrimination score. The control group receives similar audiological evaluations at 3 weeks, 6, 12, 18 and 30 months of age. Currently we are continuing to enroll control children and collect information about possible risk factors that predict SNHL in CMV infected children. None of the controls have SNHL in the first or second year of life. About 8% of the newborns with congenital CMV have SNHL, with both progression and delayed onset of hearing loss documented in the first six months of life. Our proposal will provide better knowledge of the epidemiology and natural history of SNHL due to CMV. This information is essential for planning early detection and intervention strategies for SNHL in infants and young children.

该项目的主要目标是确定流行率和 感音神经性听力进行性和/或延迟性发作的年龄 丢失(SNHL)最有可能发生在婴幼儿中，原因是 先天性巨细胞病毒(CMV)感染。我们的项目也定义了 新生儿期危险因素对CMV感染者SNHL的预测作用 临床上没有明显疾病的婴儿。我们的第三个目标定义了 巨细胞病毒感染对迟发性耳聋的相对贡献 人口数量。这些目标正在通过识别所有新生儿来实现 来自大学医院的先天性巨细胞病毒感染并连续 测试他们，以评估他们在不同年龄的听力敏感度。另外， 选择巨细胞病毒阴性的新生儿作为对照组 追踪并与CMV阳性但无听力损失的儿童进行比较 出生。所有在大学医院出生的婴儿目前都要接受筛查 研究人员对先天性巨细胞病毒感染的病毒学研究 求婚。在3周、3、6、9和12个月龄时，每个CMV阳性 婴儿由临床听力学专家进行完整的听力学评估 这包括听觉脑干诱发反应(ABR)和导抗 每只耳朵的尺寸。此外，每个孩子都有完整的听力检查 在18、24和30个月龄时进行评估，包括行为 测听评估(视觉增强或播放测听)和 获得纯音阈值的导纳措施，语音接收 阈值和言语辨别分数。对照组接受 在3周、6个月、12个月、18个月和30个月时进行类似的听力学评估 年龄。目前，我们正在继续招收控制儿童和收集 关于预测CMV感染的SNHL的可能危险因素的信息 孩子们。在第一年或第二年，所有对照组都没有发生SNHL 生活。约8%患有先天性巨细胞病毒的新生儿患有SNHL，两者都 前六名中记录的听力损失的进展和延迟发作 几个月的生命。我们的提案将更好地了解 巨细胞病毒引起的SNHL的流行病学和自然病史。此信息是 对规划早期发现和干预战略至关重要 婴幼儿的SNHL。