An investigation of current practice in the design and assessment of progression criteria in Canadian external pilot and feasibility studies

对加拿大外部试点和可行性研究进展标准设计和评估的当前实践的调查

• 批准号: NE/T014059/1
• 负责人: Sally Hopewell
• 金额: $ 1.21万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FT014059%2F1
• 关键词: investigation; current; practice; design; assessment

MRC : Katie Mellor : MR/N013468/1Randomised controlled trials allocate people, at random (by chance), to receive an intervention e.g. a specific drug or treatment, to see how effective different interventions are. These types of studies provide the best evidence about the effectiveness (and harms) of health care interventions and ensure that health care decisions are made based on good quality evidence. However, randomised controlled trials can be very complicated and expensive to run. To ensure that research can be most effective and make the best use of our limited resources, sometimes researchers conduct smaller pilot and feasibility studies before they decide to run a randomised controlled trial. These pilot and feasibility studies help them to understand whether the future randomised trial can be successfully carried out, whether they should proceed with it, and if so how. It is not always clear how the decision is made based on this initial pilot or feasibility study as to whether the future randomised trial should be run. Often, different pilot and feasibility studies have varied definitions of what they expect to find out in order to decide that a future study should be undertaken. To investigate how researchers are currently making these decisions, I will review a sample of pilot and feasibility studies that have been approved in Canada, and I will talk to some researchers who are currently, or have recently, made these decisions to see what they think should be considered, and why they think it is important.

MRC：凯蒂梅洛尔：MR/N 013468/1随机对照试验随机（偶然）分配受试者接受干预，例如特定药物或治疗，以观察不同干预的有效性。这些类型的研究提供了关于医疗保健干预措施的有效性（和危害）的最佳证据，并确保医疗保健决策是基于高质量的证据。然而，随机对照试验可能非常复杂，运行成本也很高。为了确保研究能够最有效地利用我们有限的资源，有时研究人员在决定进行随机对照试验之前进行较小的试点和可行性研究。这些试点和可行性研究有助于他们了解未来的随机试验是否可以成功进行，他们是否应该继续下去，如果是的话，如何进行。如何根据初步试验或可行性研究来决定未来是否进行随机试验并不总是很清楚。通常，不同的试点和可行性研究对他们期望发现的内容有不同的定义，以便决定未来是否应该进行研究。为了调查研究人员目前是如何做出这些决定的，我将回顾加拿大已批准的试点和可行性研究的样本，我将与一些目前或最近做出这些决定的研究人员交谈，看看他们认为应该考虑什么，以及为什么他们认为这很重要。