CORE--ASSAYS AND REAGENTS

分析和试剂核心的总体目标是提供 ART检测方法、试剂、建议、培训、帮助和 以提高成本效益、质量和 符合资格的主要调查人员所进行的研究的及时性 项目。具体地说，核心将：获取、清点和维护 符合条件的项目所需的充足的分析试剂库存(此 包括开发、批量购买、索取礼物或使用化学方法 合成第一和第二多克隆和单抗的免疫原 抗体和抗体片段、标准、其他参考和质量 对照制剂和标记有放射性碘、生物素或 酶)；对获得的试剂进行表征和测试，并使其可用 符合条件的项目；满足低流量用户、个人的需求 没有足够的实验室支持，而有其他需求的用户 提供高质量、高性价比的检测服务， 以结果为基础；采用先进的分析质量控制 所有活动中的程序；维护业绩记录、库存、 和所有试剂和检测系统的文档，由 核心；及时提供有关利用 有效的方法；开发或以其他方式实施改进的、状态 减少使用的ART分析方法和分析程序 放射性同位素，并提供更高的特异性，敏感性， 可靠性和易用性；提供以下方面的质量控制评估 向符合条件的项目提供化验和化验试剂盒；讲授化验 技术和免疫分析数据处理，并提供培训和 关于放射性和危险材料安全的通用说明 预防生物危害、实验室安全和卫生以及 适用的法规遵从性。

The overall goal of the Assays and Reagents Core is to provide state of the art assay methods, reagents, advice, training, assistance, and service in ways that will increase the cost effectiveness, quality, and timeliness of research performed by principal investigators of eligible projects. Specifically, the Core will: obtain, inventory, and maintain adequate stocks of analytical reagents needed by eligible projects (this includes developing, purchasing in bulk, requesting gifts or chemically synthesizing immunogens, first and second polyclonal and monoclonal antibodies and antibody fragments, standards, other reference and quality control preparations, and tracers labeled with radioiodide, biotin or enzymes); characterize and test acquired reagents and make them available to eligible projects; meet the needs of low volume Users, individuals with inadequate laboratory support, and Users with other needs by providing high quality, cost-effective service assays on a samples-in, results-out basis; incorporate advanced analytical quality control procedures in all activities; maintain performance records, inventories, and documentation for all reagents and assay systems provided by the Core; provide timely information, assistance, and advice in utilizing the methods effectively; develop or otherwise implement improved, state of the art assay methods and analytical procedures that reduce the use of radioactive isotopes and provide increased specificity, sensitivity, reliability and ease of use; provide quality control assessments for assays and assay kits provided to eligible projects and; teach assay technology and immunoassay data processing, and provide training and instruction in radioactive and hazardous materials safety, in universal precautions for biohazards, in laboratory safety and sanitation, and in applicable regulatory compliance.