Adherence to Antiretrovirals in People Living with HIV

艾滋病毒感染者坚持使用抗逆转录病毒药物

• 批准号: 6657208
• 负责人: Alvin Rees Midgley
• 金额: $ 10万
• 依托单位: NOTABOOK PUBLISHING, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2004-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657208
• 关键词: AIDS therapy; HIV infections; Internet; antiAIDS agent; antiviral agents; clinical research; combination chemotherapy; computer assisted patient care; computer system design /evaluation; focus groups; human subject; motivation; self care; therapy compliance

DESCRIPTION (provided by applicant): People living with HIV or AIDS (PLWHA) are often prescribed an antiretroviral regimen to decrease risk for opportunistic infection. These multi-medication regimens are highly complex and burdensome and require almost perfect adherence. Consequently, poor antiretroviral adherence is a vexing problem. We propose an engaging, literacy- and motivationally tailored interactive website intervention to promote adherence to Highly Active Anti Retroviral Therapy (HAART) among PLWHA. The website will be written at three-levels of complexity, include pop-up definitions for difficult words, and provide means to deliver feedback. Dynamic assembly of pages will permit customization and personalization. Through focus group meetings with both PLWHA and health care providers during Phase I, we will assess needs, priorities, and preferences related to website content, and gain ideas for operational features, personalized pages, and web-based communication. This information will be used to develop a pilot version of the website with a motivational-tailoring algorithm that matches content to users' readiness to adhere, Finally, we will conduct a preliminary evaluation of the new intervention's feasibility. During Phase II we will expand website features, content, and tailoring to enhance user motivation, website effectiveness, and repetitive, long-term use. We will then determine the potential effects of repeated visits to the site upon HAART-related knowledge, attitudes, and adherence dimensions, as compared to the effects of non-motivationally tailored and non-interactive versions.

描述（由申请人提供）：艾滋病毒感染者或艾滋病患者（PLWHA）经常被规定抗逆转录病毒治疗方案，以降低机会性感染的风险。这些多种药物治疗方案非常复杂和繁琐，需要几乎完美的依从性。因此，抗逆转录病毒治疗依从性差是一个令人烦恼的问题。我们提出了一个有吸引力的，识字和动机定制的互动网站干预，以促进坚持高活性抗逆转录病毒治疗（HAART）之间的艾滋病毒感染者。该网站将编写在三个层次的复杂性，包括弹出定义的困难的话，并提供手段，提供反馈。页面的动态组合将允许定制和个性化。在第一阶段，通过与艾滋病毒感染者和卫生保健提供者的焦点小组会议，我们将评估与网站内容相关的需求、优先事项和偏好，并获得关于操作功能、个性化页面和基于网络的通信的想法。这些信息将被用于开发一个试点版本的网站与动机剪裁算法，匹配内容用户的准备坚持，最后，我们将进行新的干预的可行性初步评估。在第二阶段，我们将扩展网站功能，内容和定制，以提高用户的积极性，网站的有效性和重复性，长期使用。然后，我们将确定HAART相关的知识，态度和坚持方面的潜在影响，反复访问该网站相比，非动机定制和非互动版本的影响。