The exposure of urban rodents to the human COVID-19 virus and the potential for viral recombination
城市啮齿动物接触人类 COVID-19 病毒以及病毒重组的可能性
基本信息
- 批准号:NE/V009028/1
- 负责人:
- 金额:$ 21.7万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2020
- 资助国家:英国
- 起止时间:2020 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
All of us are affected by the COVID-19 pandemic, which is caused by a virus (technically, SARS-CoV-2) that originally jumped from an animal (probably a bat) into a person. Now the virus is spreading person-to-person directly.COVID-19 is a coronavirus, and coronaviruses are very common in wild animals. While each coronavirus typically infects one species of animal, coronaviruses can move between animal species too. So the general idea is that animals are "reservoirs" of viruses that sometimes moves into people.Because so many people are getting infected with COVID-19, we think that humans might now be a virus reservoir infecting animals. If this does happen, it's most likely where there are high densities of people and of animals - such as rodents in cities, where large numbers of people and rodents live cheek-by-jowl. This is the idea we want to test.But why does this matter? Different viruses can also mix their genetics (technically, recombine), and so we also wonder if the human COVID-19 does infect rodents, whether it will then recombine with other coronaviruses already in those rodents. There are a lots of 'ifs' in these last few sentences, which is because these are just theories that we have. We now want to see if these theories - these 'ifs' - are correct. To do this we want to catch city-dwelling rats and mice that we'll then screen for the human COVID-19 virus, or close relatives of it.
我们所有人都受到COVID-19大流行的影响,这是由一种最初从动物(可能是蝙蝠)跳到人身上的病毒(技术上讲,SARS-CoV-2)引起的。现在病毒是直接在人与人之间传播,COVID-19是一种冠状病毒,冠状病毒在野生动物中非常常见。虽然每种冠状病毒通常感染一种动物,但冠状病毒也可以在动物物种之间传播。因此,一般的观点是,动物是病毒的“宿主”,有时会进入人类。由于有如此多的人感染了COVID-19,我们认为人类现在可能是感染动物的病毒宿主。如果这种情况真的发生,最有可能的地方有高密度的人和动物-如啮齿动物在城市,那里有大量的人和啮齿动物生活在一起。这就是我们要检验的观点。但为什么这很重要呢?不同的病毒也可以混合它们的基因(技术上讲,重组),因此我们也想知道人类COVID-19是否感染了啮齿动物,它是否会与已经在这些啮齿动物中的其他冠状病毒重组。在最后几句话中有很多“如果”,这是因为这些只是我们的理论。我们现在想看看这些理论--这些“如果”--是否正确。为了做到这一点,我们想捕捉城市居住的大鼠和小鼠,然后我们将筛选人类COVID-19病毒,或它的近亲。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The ecology of viruses in urban rodents with a focus on SARS-CoV-2.
- DOI:10.1080/22221751.2023.2217940
- 发表时间:2023-12
- 期刊:
- 影响因子:13.2
- 作者:
- 通讯作者:
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Mark Viney其他文献
Approaches to studying the developmental switch of <em>Strongyloides</em> – Moving beyond the dauer hypothesis
- DOI:
10.1016/j.molbiopara.2022.111477 - 发表时间:
2022-05-01 - 期刊:
- 影响因子:
- 作者:
Mark Viney;Robert Morris - 通讯作者:
Robert Morris
The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing
- DOI:
10.1186/s13071-024-06626-6 - 发表时间:
2024-12-20 - 期刊:
- 影响因子:3.500
- 作者:
Kiran Afshan;Yuchen Liu;Mark Viney - 通讯作者:
Mark Viney
Prevalence of antibodies to Encephalitozoon cuniculi in stray dogs as determined by an ELISA
通过 ELISA 测定流浪狗中兔脑炎原虫抗体的流行率
- DOI:
10.1136/vr.124.13.332 - 发表时间:
1989 - 期刊:
- 影响因子:2.2
- 作者:
W. Hollister;E. Canning;Mark Viney - 通讯作者:
Mark Viney
Control of vulval cell division number in the nematode Oscheius/Dolichorhabditis sp. CEW1.
控制线虫 Oscheius/Dolichorhabditis sp 的外阴细胞分裂数量。
- DOI:
- 发表时间:
2001 - 期刊:
- 影响因子:3.3
- 作者:
Marie;Sophie Louvet;Mark Viney;Marie;Paul W. Sternberg - 通讯作者:
Paul W. Sternberg
Acquired immunity protects against helminth infection in a natural host population: long-term field and laboratory evidence
- DOI:
10.1016/j.ijpara.2012.07.006 - 发表时间:
2012-09-01 - 期刊:
- 影响因子:
- 作者:
Richard Tinsley;Lucy Stott;Jenny York;Amy Everard;Sara Chapple;Joseph Jackson;Mark Viney;Matthew C. Tinsley - 通讯作者:
Matthew C. Tinsley
Mark Viney的其他文献
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{{ truncateString('Mark Viney', 18)}}的其他基金
Using immune cell repertoires to identify pathogen threats
使用免疫细胞库来识别病原体威胁
- 批准号:
NE/X010295/1 - 财政年份:2023
- 资助金额:
$ 21.7万 - 项目类别:
Research Grant
The structure and function of nematode pathogenicity islands
线虫致病岛的结构与功能
- 批准号:
BB/X008673/1 - 财政年份:2023
- 资助金额:
$ 21.7万 - 项目类别:
Research Grant
The determinants of measures of immune function in a wild mammal.
野生哺乳动物免疫功能测量的决定因素。
- 批准号:
NE/I022892/1 - 财政年份:2012
- 资助金额:
$ 21.7万 - 项目类别:
Research Grant
Why is infection unequal? : An inter-disciplinary approach.
为什么感染程度不平等?
- 批准号:
G0902447/1 - 财政年份:2010
- 资助金额:
$ 21.7万 - 项目类别:
Research Grant
The genetic basis of host resistance / susceptibility to parasite infection in a wild vertebrate population: a pilot study.
野生脊椎动物种群中宿主对寄生虫感染的抵抗力/易感性的遗传基础:一项试点研究。
- 批准号:
NE/H011498/1 - 财政年份:2010
- 资助金额:
$ 21.7万 - 项目类别:
Research Grant
The genetic control and the phenotypic response of major life-history traits of the nematode Caenorhabditis elegans under environmental stress.
环境胁迫下线虫主要生活史性状的遗传控制和表型响应。
- 批准号:
NE/F016964/1 - 财政年份:2009
- 资助金额:
$ 21.7万 - 项目类别:
Research Grant
Roles of hypothermia in response to environmental hypoxia: Behavioural and thermal modulation of the genetic and proteomic responses to low oxygen
低温在环境缺氧反应中的作用:遗传和蛋白质组对低氧反应的行为和热调节
- 批准号:
NE/D010845/1 - 财政年份:2007
- 资助金额:
$ 21.7万 - 项目类别:
Research Grant
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转型时期中国城市公共服务业管治模式的地理学研究
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