SYMPATHETIC FUNCTION IN ELDERLY HUMAN HYPERTENSION

本提案的总体目标是确定 其中交感神经系统（SNS）功能的年龄相关变化， 对胰岛素代谢作用的敏感性和盐敏感性 高血压是老年人高血压的一个重要原因。 我们 假设通常允许的补偿机制 对这些年龄相关变化的适应在老年高血压患者中受损， 时态 我们进一步假设，改善胰岛素 敏感性和降低血压后，六个月的有氧运动 运动训练计划将与盐的变化有关 敏感性、SNS功能和肾血流动力学（特别是 钠过滤减少）。

The overall objective of this proposal is to determine the extent to which age-related changes in sympathetic nervous system (SNS) function, sensitivity to the metabolic effects of insulin, and salt-sensitivity of blood pressure contribute to hypertension in the elderly. We hypothesize that the compensatory mechanisms which normally allow adaptation to these age-related changes are impaired in older hyper- tensives. We further hypothesize that an improvement insulin sensitivity and decrease in blood pressure following a six month aerobic exercise training program will be associated with alterations in salt sensitivity, SNS function and renal hemodynamics (specifically a decrease in filtration for sodium).