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SEX SPECIFIC GROWTH HORMONE PULSE PATTERN ON HEPATIC DRUG METABOLIZING ENZYMES

SEX SPECIFIC GROWTH HORMONE PULSE PATTERN ON HEPATIC DRUG METABOLIZING ENZYMES
肝脏药物代谢酶的性别特异性生长激素脉冲模式
批准号：
6274655
负责人：
CRAIG A JAFFE
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274655
关键词：
apolipoproteins biopsy blood chemistry blood lipoprotein bone metabolism cholesterol clinical research drug metabolism duodenum enzyme activity gene expression hormone regulation /control mechanism human subject liver metabolism messenger RNA sex hormones somatotropin urinalysis

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英文摘要
The expression of CYP3A4 and of another GH responsive hepatic enzyme, CYP1A2, and CYP3A4 mRNA will be directly measured in duodenal tissue that will be obtained through endoscopic biopsies after each treatment regimen. The effect of GH pulse pattern on lipoprotein expression and bone metabolism will also be assessed by measuring serum cholesterol and apoproteins and serum and urine markers for bone formation and resorption.
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