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EFFECT OF TROGLITAZONE ON CYP 3A4 & ON DEXAMETHASONE SUPPRESSION TEST

EFFECT OF TROGLITAZONE ON CYP 3A4 & ON DEXAMETHASONE SUPPRESSION TEST
曲格列酮对 CYP 3A4 的影响
批准号：
6303498
负责人：
CRAIG A JAFFE
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6303498
关键词：
clinical research clinical trials cytochrome P450 dexamethasone suppression test diabetes mellitus therapy drug adverse effect drug screening /evaluation enzyme activity human subject hypoglycemic agents troglitazone

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中文摘要
翻译
我们最近发现了一个病人谁有一个假阳性的低剂量地塞米松抑制试验（DST），可能是由于治疗与新的胰岛素增敏剂，曲格列酮（Rezulin）。 临床研究数据表明，曲格列酮可诱导肝脏CYP3A4，这是肝脏中最常见的药物代谢酶，也是负责地塞米松代谢的酶。我们认为，随着曲格列酮的使用越来越频繁，其适应症也越来越广泛，接受曲格列酮治疗的患者DST假阳性将变得越来越常见。拟定的研究将确定曲格列酮是否通过增加CYP3A4活性改变DST。
英文摘要
We have recently identified a patient who had a false positive low dose dexamethasone suppression test (DST) that likely resulted from treatment with a new insulin sensitizing agent, troglitazone (Rezulin). Data from clinical studies suggest that troglitazone induces hepatic CYP3A4, the most prevalent drug metabolizing enzyme in the liver and the enzyme that is also responsible for the metabolism of dexamethasone. We suggest that as troglitazone becomes more frequently used and as its indications for use broaden, false positive DST in patients treated with troglitazone will become common. The proposed investigations will establish whether troglitazone does alter DST via an increase in CYP3A4 activity.
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