RECOMBINANT INSULIN LIKE GROWTH FACTOR I (IGF-1) IN NORMAL AND ACROMEGALICS

正常和肢端健壮患者中的重组胰岛素样生长因子 I (IGF-1)

• 批准号: 6113366
• 负责人: CRAIG A JAFFE
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113366
• 关键词: acromegaly; clinical research; endocrine pharmacology; female; gender difference; growth hormone releasing hormone; hormone regulation /control mechanism; human subject; insulinlike growth factor; male; menstrual cycle; recombinant proteins; secretion; somatotropin

The control of pituitary secretion of growth hormone (GH) secretion is mediated by a complicated feedback system involving growth hormone- releasing hormone (GHRH) and somatostatin (SRIF) secretion from the hypothalamus, GH released from the anterior pituitary and locally produced and/or cirulating insulin-like growth factor I (IGF-I). The major aim of this investigation is to determine (a) if and how systemic IGF-I regulates GH secretion in normal men and women. In addition, we will (b) determine if IGF-I has a similar regulatory role in GH secretion in acromegaly and we will (c) investigate how the pattern of GH secretion changes in women during the menstrual cycle.

生长激素（GH）分泌的垂体分泌的控制由复杂的反馈系统介导，该反馈系统涉及来自下丘脑的生长激素释放激素（GHRH）和生长抑素（SRIF）分泌、来自垂体前叶的GH释放以及局部产生和/或循环的胰岛素样生长因子I（IGF-I）。 本研究的主要目的是确定（a）是否以及如何全身IGF-I调节正常男性和女性的GH分泌。 此外，我们将（B）确定IGF-I是否对肢端肥大症的GH分泌具有类似的调节作用，我们将（c）研究女性在月经周期中GH分泌模式的变化。