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RECOMBINANT INSULIN LIKE GROWTH FACTOR I (IGF-1) IN NORMAL AND ACROMEGALICS

RECOMBINANT INSULIN LIKE GROWTH FACTOR I (IGF-1) IN NORMAL AND ACROMEGALICS
正常和肢端健壮患者中的重组胰岛素样生长因子 I (IGF-1)
批准号：
6113366
负责人：
CRAIG A JAFFE
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113366
关键词：
acromegaly clinical research endocrine pharmacology female gender difference growth hormone releasing hormone hormone regulation /control mechanism human subject insulinlike growth factor male menstrual cycle recombinant proteins secretion somatotropin

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中文摘要
翻译
生长激素(GH)分泌的调控是由一个复杂的反馈系统介导的，其中包括下丘脑分泌的生长激素释放激素(GHRH)和生长抑素(SRIF)，垂体前叶释放的生长激素(GH)以及局部产生和/或调节的胰岛素样生长因子-I(IGF-I)。这项研究的主要目的是确定(A)系统性IGF-I是否以及如何调节正常男性和女性的GH分泌。此外，我们将(B)确定IGF-I是否对肢端肥大症的GH分泌具有类似的调节作用，以及(C)我们将研究女性在月经周期中GH分泌模式的变化。
英文摘要
The control of pituitary secretion of growth hormone (GH) secretion is mediated by a complicated feedback system involving growth hormone- releasing hormone (GHRH) and somatostatin (SRIF) secretion from the hypothalamus, GH released from the anterior pituitary and locally produced and/or cirulating insulin-like growth factor I (IGF-I). The major aim of this investigation is to determine (a) if and how systemic IGF-I regulates GH secretion in normal men and women. In addition, we will (b) determine if IGF-I has a similar regulatory role in GH secretion in acromegaly and we will (c) investigate how the pattern of GH secretion changes in women during the menstrual cycle.
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