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COMPARISON OF RESPONSES TO EC-5 AND EC-6 ENDOTOXIN IN NORMAL VOLUNTEERS

COMPARISON OF RESPONSES TO EC-5 AND EC-6 ENDOTOXIN IN NORMAL VOLUNTEERS
正常志愿者对 EC-5 和 EC-6 内毒素反应的比较
批准号：
6275267
负责人：
STEPHEN F LOWRY
金额：
$5.51万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275267
关键词：
Escherichia coli cell adhesion molecules clinical research cytokine dosage endotoxins human subject interleukin 10 interleukin 6 toxin metabolism tumor necrosis factor alpha

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中文摘要
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英文摘要
This study seeks to define the in vivo and in vitro responses to a new lot of E.coli endotoxin (EC-6) and compare these to those derived from its predecessor EC-5. Normal subjects will be studied for dose-response and time-action effects to both endotoxins. Parameters measured will include selected cytokines (TNF,IL-6, IL-10), cell surface receptors and immunocyte function.
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