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EFFECT OF TNF RECEPTOR-IGG FUSION PROTEIN ON SYSTEMIC INFLAMMATORY RESPONSES

EFFECT OF TNF RECEPTOR-IGG FUSION PROTEIN ON SYSTEMIC INFLAMMATORY RESPONSES
TNF 受体-IGG 融合蛋白对全身炎症反应的影响
批准号：
6275225
负责人：
STEPHEN F LOWRY
金额：
$5.51万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275225
关键词：
chimeric proteins clinical research cytokine receptors endotoxins human subject human therapy evaluation immunoglobulin G immunotherapy inflammation intravenous administration recombinant proteins tumor necrosis factor alpha

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中文摘要
翻译
内毒素血症与肿瘤坏死因子的出现有关， 流通。为了评估TNF在全身炎症反应中的作用， 内毒素诱导的反应，健康人将静脉内 注射内毒素，伴或不伴30分钟静脉输注 重组肿瘤坏死因子受体-IgG融合蛋白， 可以中和肿瘤坏死因子的活性。
英文摘要
Endotoxemia is associated with the appearance of tumor necrosis factor in the circulation. To assess the role of TNF in the systemic inflammatory responses induced by endotoxin, healthy humans will be intravenously injected with endotoxin with or without a 30-minute intravenous infusion of a recombinant tumor necrosis factor receptor-IgG fusion protein, which is known to neutralize tumor necrosis factor activity.
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EFFECT OF TNF RECEPTOR-IGG FUSION PROTEIN ON SYSTEMIC INFLAMMATORY RESPONSES
PARENTERAL GLUTAMINE DIPEPTIDE SUPPLEMENTATION
EPINEPHRINE EFFECT ON SYSTEMIC INFLAMMATORY RESPONSES IN ENDOTOXEMIA
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