EFFECTS OF COMPULSIVE EDUCATIONAL BEHAVIOR HTN AFRICAN AMERICAN MEN

强制教育行为 HTN 对非洲裔美国男性的影响

• 批准号: 6275662
• 负责人: WENDY S POST
• 金额: $ 2.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275662
• 关键词: angiotensin /renin /aldosterone hypertension; angiotensin II; cardiovascular disorder education; clinical research; echocardiography; electrocardiography; familial hypertension; genetic polymorphism; health behavior; heart dimension /size; human subject; longitudinal human study; male; outcomes research; patient care management; renin; renin angiotensin system; ventricular hypertrophy

The purpose of this supplement to Dr. Martha Hill's YBMII hypertension study, is to evaluate the difference in left ventricular mass (LVM), measured with echocardiography, between the men in the special intervention versus the men in the usual care group. The hypothesis is that the special intervention will lead to a smaller increase in LVM over 2 years of follow-up than the usual care group, or to a reduction in LVM. In addition, we are measuring changes in voltage on ECG, as a secondary measure of LVM regression, and carotid tonometry measurement of augmentation index as a measure of central vascular stiffness. Plasma renin and angiotensin II are measured to define the presence of low renin hypertension in this group of African-American men. The buffy coat is saved for DNA analysis of genetic polymorphisms related to the renin-angiotensin system. We will analyze the association between renin and angiotensin II levels and left ventricular hypertrophy, and also the association between genetic polymorphisms and left ventricular hypertrophy.

玛莎·希尔博士的YBMII高血压的这一补充资料的目的 这项研究旨在评估左心室重量(LVM)的差异， 用超声心动图测量，在特殊的男人之间 干预与常规护理组中男性的对比。假说 是特殊干预将导致LVM较小的增长 比常规护理组随访2年以上，或减少 在LVM中。此外，我们正在测量心电图上的电压变化，作为 LVM回归的二次测量和颈动脉测压 将增强指数作为衡量中央血管僵硬程度的指标。 测定血浆肾素和血管紧张素II以确定 在这组非裔美国男性中，肾素水平偏低。《巴菲》 保留外套用于DNA分析与基因多态相关的 肾素-血管紧张素系统。我们将分析肾素与 和血管紧张素II水平和左心室肥厚，还有 遗传多态与左心室的相关性研究 肥大。