DO VOLATILE ANESTHETICS MODULATE BENZODIAZEPINE BINDING TO CEREBRAL NEURONS

挥发性麻醉剂会调节苯二氮卓类药物与大脑神经元的结合吗

• 批准号: 6275819
• 负责人: LEONARD FIRESTONE
• 金额: $ 1.91万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275819
• 关键词: benzodiazepine receptor; benzodiazepines; drug interactions; drug receptors; human subject; isoflurane; midazolam; neurons; neuropharmacology; positron emission tomography; receptor binding

This protocol will use PET technology to determine if isoflurane anesthesia changes binding of 11C-flumazenil, a GABA agonist, to its receptor in different regions of the brain. Binding will be measured by the Bmax/KD quotient. This study will determine if isoflurane anesthesia changes the binding of the GABA antagonist midazolam in the interaction studies using combinations of 11C-flumazenil, unlabeled midazolam and isoflurane anesthesia.

本协议将使用PET技术来确定是否异氟醚