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DO VOLATILE ANESTHETICS MODULATE BENZODIAZEPINE BINDING TO CEREBRAL NEURONS

DO VOLATILE ANESTHETICS MODULATE BENZODIAZEPINE BINDING TO CEREBRAL NEURONS
挥发性麻醉剂会调节苯二氮卓类药物与大脑神经元的结合吗
批准号：
6275819
负责人：
LEONARD FIRESTONE
金额：
$1.91万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275819
关键词：
benzodiazepine receptor benzodiazepines drug interactions drug receptors human subject isoflurane midazolam neurons neuropharmacology positron emission tomography receptor binding

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中文摘要
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英文摘要
This protocol will use PET technology to determine if isoflurane anesthesia changes binding of 11C-flumazenil, a GABA agonist, to its receptor in different regions of the brain. Binding will be measured by the Bmax/KD quotient. This study will determine if isoflurane anesthesia changes the binding of the GABA antagonist midazolam in the interaction studies using combinations of 11C-flumazenil, unlabeled midazolam and isoflurane anesthesia.
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IN VIVO PET IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN
DO VOLATILE ANESTHETICS MODULATE BENZODIAZEPINE BINDING TO CEREBRAL NEURONS
IN VIVO PET IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN
IN VIVO IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN
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