IN VIVO PET IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN

人脑中挥发性麻醉作用 5HT2A 受体的体内 PET 成像

• 批准号: 6114575
• 负责人: LEONARD FIRESTONE
• 金额: $ 2.9万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114575
• 关键词: anesthetics; bioimaging /biomedical imaging; clinical research; human subject; isoflurane; positron emission tomography; radiotracer; serotonin receptor

The mechanisms of volatile general anesthetics remain unclear. One of the putative targets for volatile general anesthetics is the brain serotonin receptor. This study will test the hypothesis that the 5HT2A receptor will not show a conformational change from anesthesia. The binding of the radiotracer 18F-altanserin will be measured by PET in the presence of an anesthetizing concentration of isoflurane to that in isoflurane's absence will be compared.

挥发性全身麻醉药的作用机制尚不清楚。其中一个 挥发性全麻药的假定靶点是大脑中的5-羟色胺 受体。这项研究将检验5HT2a受体的假设 不会表现出麻醉后的构象变化。的约束性 放射性示踪剂18F-Altanserin将在存在的情况下用PET测量 异氟醚的麻醉浓度与无异氟烷时的麻醉浓度 将会被比较。